简略探讨急性胰腺炎凝血功能的变化  

To probe the changes of blood coagulation fuction in patients with acute pancreatitis.

作　　者：马旭[1] 金俊哲[1] 姜洪磊[1] 刘武[1] 梁健[1] 

机构地区：[1]中国医科大学附属第四医院肝胆外科,辽宁沈阳110001

出　　处：《中国医学装备》2014年第B12期220-221,共2页China Medical Equipment

摘　　要：目的:探讨急性胰腺炎(AP)患者凝血功能的变化及临床意义。方法:将65例急性胰腺炎患者作为病例组,并按照病情程度分为轻度组(n=24)、中度组(n=25)和重度组(n=16),并选取同时期门诊健康体检者50例作为对照组。对所有人员采用全自动血凝分析仪检测其凝血酶原时间(APTT)、活化部分凝血酶时间(PT)、血小板计数(BPC)以及纤维蛋白原浓度(FIB),并进行统计学处理和相关性分析。结果:病例组PT、APTT、FIB显著高于对照组,BPC显著低于对照组,差异有统计学意义(P<0.05);重度组PT、APTT、FIB、APACHEⅡ评分显著高于轻度组和中度组,BPC显著低于轻度组和中度组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,PT、APTT、FIB与患者APACHEⅡ评分呈正相关,BPC与APACHEⅡ评分呈负相关(r<0,P<0.05)。结论:急性胰腺炎患者凝血功能与病情严重程度密切相关,测定凝血功能的变化对评估AP患者的病情轻重与判断预后有着一定的意义。Objective： To study the blood coagulation function in patients with acute pancreatitis （AP） changes and the clinical significance. Methods： 65 patients with acute pancreatitis as case group, and in accordance with the severity of disease were divided into mild group （n=24）, the moderate group （n=25） and severe group （n=16）, and select the out-patient health examination during the same period in 50 cases as control group. For all personnel using full automatic blood coagulation analyzer to detect the prothrombin time （APTT）, activated partial thromboplastin time （PT）, platelet count （BPC） and fibrinogen （FIB）, and through the analysis of statistical processing and correlation. Results： The case group PT, APTT, FIB were significantly higher than that of the control group, BPC was significantly lower than that of the control group, the difference was statistically significant （P 〈 0.05）; severe group PT, APTT, FIB, APACHE II score was significantly higher than that of mild group and moderate group, BPC was significantly lower than that of the mild group and moderate group, the difference was statistically significant （P 〈 0.05）; correlation analysis showed Pearson, PT, APTT, FIB in patients with APACHE score was positively correlated, negatively correlated with BPC （r 〈 0, P 〈 0.05）. Conclusion： Closely related to blood coagulation function of acute pancreatitis patients and the severity of the disease, has a certain significance of the changes of coagulation function for evaluating AP determination in patients with the severity and prognosis.

关 键 词：急性胰腺炎 凝血功能 凝血和纤溶系统 

分 类 号：R576[医药卫生—消化系统]