P53及nm23在不同分子亚型浸润性乳腺癌中的表达及意义  

Expression and significance of P53 and nm23 in different molecular subtypes of breast carcinoma

作　　者：高玉霞[1] 沈媛[1] 

机构地区：[1]河北省廊坊市人民医院病理科,河北廊坊065000

出　　处：《诊断学理论与实践》2015年第1期58-61,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的 :研究P53及nm23在不同分子亚型浸润性乳腺癌中的表达及其意义。方法 :将275例浸润性乳腺癌患者分为激素受体阳性、HER2受体阳性及三阴性3组,采用免疫组织化学法检测其P53及nm23蛋白的表达水平。结果:P53在激素受体阳性组、HER2受体阳性组、三阴性组中的表达率分别为38.9%、73.5%及77.3%,3组间的P53表达有统计学意义差异(χ2=30.662,P<0.05),以三阴性组表达最高;nm23在激素受体阳性组、HER2受体阳性组、三阴性组中的表达率分别为84.3%、67.6%及54.5%,3组间差异有统计学意义(χ2=15.515,P<0.05),以三阴性组及HER2阳性组表达较低。有腋窝淋巴结转移的乳腺癌患者的P53表达阳性率高于无腋窝淋巴结转移者,差异有统计学意义(χ2=5.502,P<0.05);而无腋窝淋巴结转移者的nm23表达阳性率高于有腋窝淋巴结转移者,差异亦有统计学意义(χ2=21.196,P<0.05)。结论:在不同分子亚型的乳腺癌中联合检测P53及nm23,可作为评价乳腺癌发生、发展的指标,更有助于临床治疗和预后判断。Objective： To investigate the expression and significance of P53 and nm23 in different molecular subtypes of breast carcinoma. Methods： The expression of ER、PR、HER2、P53 and nm23 were detected immunohistochemically in275 specimens of invasive breast carcinoma. Results： Positive expression rates of P53 were 38.9% in ER/PR（＋） group,73.5% in HER2（＋）group, and 77.3% in triple negative breast cancer group. Significant differences in positive expression rates of P53 between the 3 groups were seen（ χ^2=30.662, P 0.05）, with the highest expression level in triple negative breast cancer group. The positive expression rates of nm23 were 84.3% in ER/PR（＋）group, 67.6% in HER2（＋）group and54.5% in triple negative breast cancer group. Significant differences in positive expression rates of nm23 were found be-tween the 3 groups（ χ^2=15.515, P〈0.05）, and the expression rates were lower in HER2（＋） group and triple negative breast cancer group. Patients with axillary lymph nodes metastasis had a higher positive expression rate of P53 than those without axillary lymph nodes metastasis（ χ^2=5.502, P〈0.05）, while expression of nm23 was the contrary（ χ^2=21.196, P〈0.05）.Conclusions： Combined detection of P53 and nm23 in breast carcinoma of different molecular subtypes may contribute to the guidance of clinical treatment and prognosis prediction.

关 键 词：P53 NM23 分子亚型 乳腺癌 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]