血清可溶性Fas评判浅表性膀胱癌复发的意义  

The significance of serum soluble Fas in judging recurrence of non-muscle invasive bladder cancer

作　　者：武程[1] 张鹏 倪浩东[1] 钟伟 

机构地区：[1]南通大学附属东台医院泌尿外科,江苏盐城224200 [2]国家安监总局煤炭总医院泌尿外科,北京100028

出　　处：《东南大学学报（医学版）》2015年第2期231-234,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨血清可溶性Fas(s Fas)与浅表性膀胱癌复发之间的关系。方法:将我院2006年1月至2009年12月69例术后病理确诊为浅表性膀胱癌患者作为实验组,随机选取40名健康者作为对照组,两组均空腹抽取静脉血,用双抗体夹心酶联免疫吸附法(ELISA)进行血清s Fas水平检测并对结果进行比较;根据3年内复发情况,将实验组膀胱癌患者分为复发组与无复发组,比较两组血清s Fas水平。结果:实验组复发18例,进展为肌肉浸润性膀胱癌(MIBC)13例。实验组血清s Fas水平为(0.15±0.13)ng·ml-1,对照组为(0.07±0.01)ng·ml-1,两组差异具有统计学意义(P<0.05)。复发组血清s Fas水平为(0.16±0.08)ng·ml-1,无复发组为(0.09±0.04)ng·ml-1,两组差异具有统计学意义(P<0.05);进展为MIBC者血清s Fas水平为(0.15±0.07)ng·ml-1,未进展为MIBC者为(0.14±0.03)ng·ml-1,两组差异无统计学意义(P>0.05)。采用多元线性回归模型校正各因素后得出,膀胱灌注及血清s Fas值是预测膀胱癌复发的独立因素;而膀胱癌肿瘤直径、G3分级及膀胱灌注是预测膀胱癌进展为MIBC的独立因素。结论:血清s Fas可以作为预测浅表性膀胱癌复发的标志物,浅表性膀胱癌患者术前血清s Fas水平可反映膀胱癌患者复发情况。Objective： To explore the relationship between the serum soluble Fas（ s Fas） and recurrence of nonmuscle invasive bladder cancer. Methods： 69 patients with non-muscle invasive bladder cancer diagnosised by postoperative pathology were choosed as experimental group in our hospital from January 2006 to December 2006,and 40 healthy patients were randomly selected as control group. Double antibody sandwich enzyme- linked immunosorbent（ ELISA） was used to detect the serum level of s Fas. According to the recurrent in three years,the experimental group was divided into two group with bladder cancer recurrence and non-recurrence,their serum s Fas level was compared. Results： 18 cases grow back in this study,13 cases progress of MIBC. The values of serum s Fas was（ 0. 15 ± 0. 13） ng · ml^-1in experimental group and（ 0. 07 ± 0. 01） ng · ml^-1in control group,the difference was significant（ P〈0. 05）. Furthermore,the value of serum s Fas in recurrence group [（ 0. 16 ± 0. 08）ng·ml^-1]was higher than that of the recurrence-free group[（ 0. 09 ± 0. 04） ng·ml^-1]（ P〈0. 05）,and the value of serum s Fas in MIBC group [（ 0. 15 ± 0. 07） ng · ml^-1] was slightly higher than that of the non-MIBC group[（ 0. 14 ± 0. 03） ng·ml^-1]（ P〈0. 05）. By multiple linear regression model,bladder perfusion and serum s Fas values were independent factors predicting recurrence of bladder cancer. Bladder tumor diameter,grade of G3 and bladder perfusion were predictors of progression to MIBC. Conclusion： Serum s Fas is associated with recurrence of superficial bladder cancer,and preoperative serum s Fas level of superficial bladder cancer patients can reflect the recurrence.

关 键 词：膀胱癌 可溶性FAS 复发 

分 类 号：R737.14[医药卫生—肿瘤]