JAK/STAT通路与脑缺血损伤研究进展  

Role of JAK/STAT Pathway in Cerebral Ischemia Injury

作　　者：何畏[1] 方伟蓉[1] 李运曼[1] 

机构地区：[1]中国药科大学生理教研室,南京210009

出　　处：《药学与临床研究》2015年第2期164-167,共4页Pharmaceutical and Clinical Research

基　　金：多靶点抗脑缺血新药MA的研究与开发(化Ⅰ类);国家科技重大专项"重大新药创制"(候选药物)(No.2009ZX09103-093)

摘　　要：脑缺血损伤是十分复杂的病理过程,伴随着一系列的炎症、氧化应激等反应。在脑缺血损伤中,细胞因子发挥了重要作用。JAK/STAT信号转导通路与脑缺血密切相关,是调节脑缺血后细胞因子反应的关键通路,能够调节基因转录模式的变化,进而引起细胞存活或死亡而影响脑缺血损伤。因此,了解并掌握JAK/STAT通路与脑缺血损伤之间的关系具有重要意义,能为抗脑缺血药物研究提供另一种思路。本文对JAK/STAT通路、JAK/STAT通路与脑缺血损伤的关系以及与JAK/STAT通路相关的抗脑缺血药物研究进行综述,为抗脑缺血药物的研发提供一定的参考。Ischemic cerebral injury is a complex pathological process, which causes neuronal necrosis and generates inflammations. Cytokines are major mediators of the inflammatory response after cerebral ischemia. JAK(Janus kinase)/STAT(signal transducer and activator of transcription) pathway plays a critical role in the intracellular responses to cytokines in ischemic brain, which induces alterations in the pattern of gene transcription that are associated either with cell death or survival. Therefore, it may provide another way to study the drugs of anti cerebral ischemia with JAK/STAT as the therapeutic target. This review introduces and summarizes the critical role of JAK/STAT pathway in cerebral ischemia injury, which may provide reference for the drug of anti cerebral ischemia in the future.

关 键 词：脑缺血 细胞因子 炎症反应 JAK/STAT 

分 类 号：R743.31[医药卫生—神经病学与精神病学]