口腔癌患者放疗期间口腔感染的相关因素分析  

Factors for oral infections in patients with oral cancer undergoing radiotherapy

作　　者：曾定芬[1] 李晓霞[1] 孙荣昊[1] 江华[1] 范玉霞[1] 阳静[1] 

机构地区：[1]四川省肿瘤医院头颈外科二病区,成都610041

出　　处：《中华耳鼻咽喉头颈外科杂志》2015年第4期295-299,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

摘　　要：目的 探讨接受放疗的口腔癌患者发生口腔感染的相关因素.方法 选择2012年3月至2014年5月四川省肿瘤医院头颈外科因口腔癌接受放疗患者241例为研究对象.采用SPSS17.0软件中的单因素分析方法,分析口腔癌放疗患者发生口腔感染的相关因素,再将有统计学意义的变量进行多因素Logistic回归分析.结果 241例患者中93例（38.59％）发生口腔感染.93例发生口腔感染的患者中49例（52.69％）为真菌感染,44例（47.31％）为细菌感染,38例（40.86％）为混合感染.93例口腔感染患者中55例（59.14％）是在放疗4周以后发生的感染.多因素Logistic回归分析显示,口腔癌放疗后发生口腔感染的影响因素包括：临床分期、口腔健康习惯、居住地、是否同步放化疗及手术（P值均＜0.05）.结论 口腔癌放疗患者口腔感染多发生在放疗中后期.其中疾病临床分期晚、口腔健康习惯不良、城镇人口、放化疗同步及有手术史是导致口腔癌患者放疗后口腔感染发生的重要危险因素。Objective To investigate the factors associated with oral infections in patients with oral cancer undergoing radiotherapy.Methods Clinical data of 241 patients with oral cancer undergoing radiotherapy between March 2012 and May 2014 in sichuan cancer hospital were reviewed.Univariate and multivariate analyses were performed to determine the factors related to oral infection occurring in the patients.SPSS 17.0 software was used to analyze the data.Results Ninety-three （38.59%） of 241 cases had oral infection.Among the 93 cases,49 （52.69%） cases presented with fungal infections,44 （47.31%） cases with bacterial infection,and 38 （40.86%） cases with mixed infection.Oral infection occurred since the fifth week after radiotherapy in 55 （59.14%） patients.Multivariate Logistic regression analysis showed that the risk factors for oral infection after radiotherapy were the late stage of cancer,poor oral health habits,the coexistence of multiple treatments,city dwellers and surgical history （all P 〈0.05）.Conclusions Oral infections commonly occur in the late period of radiotherapy.The late stage of cancer,poor oral health habits,the coexistence of multiple treatments,city dwellers and surgical history are key risk factors for oral infection in patients with oral cancer undergoing radiotherapy.

关 键 词：口腔 癌 放射疗法 细菌感染 危险因素 

分 类 号：R739.8[医药卫生—肿瘤]