CT引导射频消融术治疗晚期非小细胞肺癌的近期临床疗效观察  

CT-guided radiofrequency ablation for the treatment of advanced non-small cell lung cancer:observation of clinical short-term efficacy

作　　者：李辉[1] 武明辉[1] 阚晓静[1] 陈翠云[1] 吴景忠[1] 

机构地区：[1]河南省人民医院放射科,郑州450003

出　　处：《介入放射学杂志》2015年第4期320-322,共3页Journal of Interventional Radiology

基　　金：河南省卫生厅科技攻关项目(2011020145)

摘　　要：目的探讨CT引导射频消融术治疗晚期非小细胞肺癌(NSCLC)的近期临床疗效。方法 2010年6月—2013年6月期间收治的100例晚期NSCLC患者,随机将其分成对照组和观察组,每组患者各50例,其中对照组患者给予同步放化疗治疗,观察组患者给予CT引导射频消融术(RFA)治疗,比较两组患者的临床疗效、治疗前后CT值改善情况、体力状况改善情况以及术后并发症情况。结果观察组患者疾病缓解率(86.0%)明显高于对照组(52.0%)(P<0.05)、治疗后CT值(14.1±3.9)HU明显低于对照组患者(29.8±4.7)HU(P<0.05)、体力改善率(66.0%)明显高于对照组患者(44.0%)(P<0.05);观察组患者术后肺部感染、胸痛、发热、胸腔积液以及胃肠道反应发生率均明显低于对照组(P<0.05)。结论 CT引导RFA能够提高晚期NSCLC患者的临床治疗效果,改善患者的生存质量,且安全性高,创伤小,值得临床推广应用。Objective To investigate the short- term efficacy of CT- guided radiofrequency ablation（RFA） for the treatment of advanced non- small cell lung cancer. Methods During the period from June2010 to June 2013, a total of 100 patients with advanced non- small cell lung cancer were admitted to authors＇ hospital. The patients were equally and randomly divided into the study group（n=50） and the control group（n=50）. The patients of the control group received concurrent radiotherapy and chemotherapy treatment,while the patients of the study group received CT- guided RFA. The clinical effect, changes in CT values after the treatment, the improvement of physical condition and postoperative complications were recorded, and the results were compared between the two groups. Results The remission rate of the disease in the study group was 86.0%, which was much higher than that in the control group（52.0%）, and the difference between the two groups was statistically significant（P〈0.05）. After the treatment, the CT value of the study group was（14.1±3.9） HU, which was significantly lower than that of the control group（29.8±4.7 HU, P〈0.05）. The physical improvement rate of the study group（66.0%） was significantly higher than that of the control group（44.0%）, the difference between the two groups was statistically significant（P〈0.05）. The occurrence of postoperative complications, such as pulmonary infection, chest pain, fever, thoracic effusion and gastrointestinal reaction, in the study group was strikingly lower than that in the control group（P〈0.05）.Conclusion For the treatment of advanced non- small cell lung cancer, CT- guided radiofrequency ablation is safe and less- invasive, it can improve the clinical short- term effect as well as the quality of life. Therefore,this technique should be recommended in clinical practice.

关 键 词：射频消融术 非小细胞肺癌 近期疗效 

分 类 号：R734.2[医药卫生—肿瘤]