艰难梭菌相关肠道疾病的研究进展  

Clostridium difficile-associated intestinal diseases

作　　者：肖新云 赵先平[1] 谭周进[1] 

机构地区：[1]湖南中医药大学医学院微生物教研室,湖南省长沙市410208

出　　处：《世界华人消化杂志》2015年第10期1539-1545,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81173214~~

摘　　要：艰难梭菌(Clostridium difficile,CD)是一种G+厌氧芽胞粗大杆菌,是人和动物肠道中的正常菌群,可引起机会性感染,出现CD相关性腹泻、CD相关性肠炎等肠道疾病,在国内外出现过大规模流行,是全球面临的公共健康问题.CD的主要致病毒素是A毒素、B毒素和近年来新发现的二元毒素(CDT毒素),对于其防治可采用合理的护理措施和采用新型抗菌药物、CD疫苗、中药复方、微生态制剂等进行临床治疗.Clostridium difficile（CD）,as one of the normal flora in human and animal intestine,is a Gram-positive anaerobic bacillus.It could cause opportunistic infections,resulting in CDassociated diarrhea,CD-associated colitis and other intestinal diseases.There have ever been massive epidemics of CD infection in both China and other countries,and it has became a global public health problem.The main pathogenic toxins of CD are toxin A,toxin B and newly discovered binary toxins（CDT）.For CD infection prevention and treatment,the reasonable use of new antimicrobial drugs,traditional Chinese medicine,probiotics,CD vaccine and other clinical treatments can be adopted.

关 键 词：艰难梭菌 肠道疾病 致病机制 临床症状 防治 

分 类 号：R574[医药卫生—消化系统]