肠易激综合征细胞因子失衡与肠黏膜屏障损伤的相关性  

Association between cytokine imbalance and intestinal barrier injury in irritable bowel syndrome

作　　者：陈婷[1] 唐旭东[2] 王凤云[2] 康楠[2] 王晓鸽[2] 

机构地区：[1]中国中医科学院研究生院,北京市100700 [2]中国中医科学院西苑医院,北京市100091

出　　处：《世界华人消化杂志》2015年第10期1597-1602,共6页World Chinese Journal of Digestology

基　　金："十二五"国家科技支撑计划基金资助项目;No.2013BA I02B05;国家自然基金面上基金资助项目;Nos.81373580;81173209;中央级公益性科研院所基本科研业务费专项基金资助项目;No.ZZ070801~~

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)作为临床常见病与多发病,目前已受到越来越多的关注.近些年来,随着细胞生物学和分子生物学的研究不断开展及PI-IBS概念的提出,对于IBS相关病理机制的探讨已逐渐由功能性向器质性过渡.为了将更加实用的药物应用于IBS的临床治疗,研究者逐渐着眼于IBS与炎性因子失衡、肠黏膜屏障损伤的相关性研究.探讨IBS细胞因子失衡与肠黏膜损伤的相关性,是为了在探寻IBS有效治疗药物的征途中开发和评估新的治疗措施,为更好的治疗本病提供新的思路.As a common and frequently-occurring disease,irritable bowel syndrome（IBS） has been paid more and more attention.In recent years,with the development of cell biology and molecular biology,the research on IBS has been shifted from functional to organic direction.Studying the association between cytokine imbalance and intestinal barrier injury in IBS is aimed to assess a more meaningful treatment for IBS in the process of searching for effective drugs,so as to provide new avenues for better treatment of the disease.

关 键 词：肠易激综合征 细胞因子失衡 肠黏膜屏障损伤 

分 类 号：R574.4[医药卫生—消化系统]