儿童恶性血液病并发毛细血管渗漏综合征的危险因素分析  

Risk factors for capillary leak syndrome in children with hematological malignancies

作　　者：任颖[1] 刘述[2] 杨月明 刘洪军[4] 

机构地区：[1]皖南医学院附属弋矶山医院儿科,安徽芜湖241001 [2]中山大学中山医学院人体解剖教研室,广东广州510080 [3]大连市妇女儿童医疗中心儿童血液肿瘤科,辽宁大连116000 [4]安徽医科大学附属安徽省立医院儿科,安徽合肥230001

出　　处：《南方医科大学学报》2015年第4期606-609,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(S2012010009215)

摘　　要：目的探讨儿童恶性血液病并发毛细血管渗漏综合征(CLS)发生的危险因素,提高对儿童恶性血液病并发毛细血管渗漏综合征的临床认识。方法采用30例儿童恶性血液病发生CLS患儿的临床资料,对CLS发生的高危因素进行多元logistic回归分析。结果在0.05检验水准下,有无低氧血症,有无败血症与应变量之间的联系有统计学意义,CLS前白细胞数目,有无严重骨髓抑制在检验水准附近。结论毛细血管渗漏综合征为儿童恶性血液病治疗过程中的少见急重症,低氧血症和败血症是儿童恶性血液病并发CLS的危险因素,儿内科医师应引起重视。Objective To investigate the risk factors for capillary leak syndrome （CLS） in children with malignant hematologic diseases. Methods Thirty children with hematological malignancies complicated with CLS were analyzed with multiple logistic regression analysis. Results At the test level of 0.05, hypoxemia and septicemia were found to significantly correlate with CLS in these children, and the number of white blood cells before CLS and severe bone marrow suppression were near the test level. Conclusion Hypoxemia and septicemia are risk factors for CLS in children with malignant hematologic diseases.

关 键 词：儿童恶性血液病 毛细血管渗漏综合征 危险因素 

分 类 号：R733[医药卫生—肿瘤]