C-myb和p53在甲状腺乳头状癌中的表达及临床意义  

Expressions of C-myb and p53 in Papillary Thyroid Cancer and Their Clinical Significance

作　　者：刘福学[1,2] 夏青生[2] 邱杰[3] 刘晓露[3] 李圆[3] 

机构地区：[1]潍坊医学院,山东潍坊261053 [2]青岛市市立医院东院区,山东青岛266000 [3]青岛大学附属医院,山东青岛266000

出　　处：《肿瘤学杂志》2015年第4期320-324,共5页Journal of Chinese Oncology

基　　金：青岛市科技局项目(13-1-4-166-jch)

摘　　要：[目的]探讨甲状腺乳头状癌中C-myb、p53的表达及其临床意义。[方法]采用免疫组化(SP)法研究38例甲状腺乳头状癌及癌旁组织,22例甲状腺瘤及腺瘤周围组织中C-myb、p53的表达。[结果 ]C-myb在甲状腺乳头状癌组织、甲状腺腺瘤、癌旁组织及腺瘤周围组织中表达的阳性率分别为86.8%、63.6%、10.5%、4.5%;p53则分别为81.6%、22.7%、0、0。C-myb、p53蛋白在甲状腺乳头状癌、癌旁组织、甲状腺腺瘤及腺瘤周围组织中表达差异均有统计学意义(P<0.05)。[结论]C-myb、p53在甲状腺组织中的异常表达与甲状腺乳头状癌发生发展相关。[Purpose] To investigate the expressions of C-myb and p53 in papillary thyroid cancer（PTC） and their significance.[Methods] Immunohistochemical staining（SP） was used to detect the expressions of C-myb and p53 in tissues of 38 cases with PTC and cancer adjacent,and 22 cases with adenoma and adenoma adjacent.[Results] The positive expression rate of C-myb was 86.8%,63.6%,10.5% and 4.5% in PTC,adenoma,cancer adjacent tissues and adenoma adjacent tissues respectively,and that of p53 was 81.6%,22.7%,0 and 0 respectively. There was significant difference of C-myb or p53 among various thyroid tissues（P〈0.05）. [Conclusion] The abnormal expressions of C-myb and p53 in thyroid tissues play important roles in carcinogenesis of PTC.

关 键 词：C-MYB P53 甲状腺肿瘤 乳头状癌 腺瘤 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]