转移性结直肠癌动物模型的研究进展  

Research Progress in Animal Model of Metastatic Colorectal Cancer

作　　者：孙钰[1] 严卿莹 阮善明[3] 沈敏鹤[3] 

机构地区：[1]嘉兴市中医医院,浙江嘉兴314000 [2]浙江中医药大学,浙江杭州310000 [3]浙江省中医院,浙江杭州310027

出　　处：《肿瘤学杂志》2015年第4期335-339,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金(81373632);浙江省中医药优秀青年人才基金计划(2013ZQ011)

摘　　要：通过综述转移性结直肠癌动物模型的建立方式,分析各种动物模型的优缺点及应用范围,从而选择合适的动物模型。在掌握熟练实验技术的同时,不断深入发展转移性结直肠癌的动物模型,研究其发生、发展的病理机制,以指导研究抗肿瘤药物的筛选,在临床上对改善结直肠癌患者的生存质量具有重要的作用。After reviewing the establishing metastatic colorectal cancer animal model,the advantages and disadvantages and the range of application of all kinds of animal models are analyzed,in order to choose the suitable animal model.With skilled experiment technology,further development of metastatic colorectal cancer animal model should be studied,in order to study the development of pathological mechanism of metastatic colorectal cancer,and to guide the screening of anticarcinogen,to improve the quality of life in patients with colorectal cancer.

关 键 词：结直肠肿瘤 动物模型 

分 类 号：R735.3[医药卫生—肿瘤]