肝癌及癌间质MMP-9表达及其与血管生成拟态的关系  

The expression of matrix metalloproteinase-9 in hepatocellular carcinoma and cancer stroma and its relationship with vasculogenic mimicry

作　　者：翁剑武[1] 林丽琳[1] 刘彪[1] 

机构地区：[1]莆田学院基础医学院,福建莆田351100

出　　处：《包头医学院学报》2015年第3期3-4,79,共3页Journal of Baotou Medical College

基　　金：福建省省级大学生创新创业训练计划项目(CXCY1304)

摘　　要：目的:探讨原发性肝细胞癌(hepatocellular carcinoma,HCC)中癌细胞与间质中基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)的表达及其与血管生成拟态(vasculogenic mimicry,VM)的关系。方法:收集原发性肝细胞癌手术切除后留取的癌组织,通过免疫组织化学检测肝癌细胞及间质细胞MMP-9的表达情况,分析其表达与VM的关系。结果:VM表达阳性组中癌细胞和间质细胞的MMP-9阳性表达率分别明显高于VM阴性组,差异具有统计学意义(χ2=4.234,P=0.039;χ2=4.167,P=0.041)。结论:MMP-9可能参与并促进VM的形成。Objective： To investigate the expression of matrix metalloproteinase- 9（ MMP- 9） in hepatocellular carcinoma（ HCC） and cancer stroma and its relationship with vasculogenic mimicry（ VM）. Methods： The removed HCC tissue after operation was collected,with the expression of matrix metalloproteinase- 9 in hepatocellular carcinoma and cancer stroma detected by immunohistochemistry and its relationship with VM analyzed as well. Results： The positive rates of the MMP- 9 expression of HCC and cancer stroma in the VM- positive group were significantly higher than those in the VM- negative group,respectively（ χ2= 4. 234,P = 0. 039; χ=4. 167,P = 0. 041）. Conclusion： The MMP- 9 may be involved in and promote the formation of VM.

关 键 词：原发性肝细胞癌 血管生成拟态 基质金属蛋白酶-9 

分 类 号：R735.7[医药卫生—肿瘤]