托莫西汀与哌甲酯缓释片治疗注意缺陷多动障碍对照研究  

A control study of atomoxetine vs methylphenidate sustained release tablets in attention deficit hyperactivity disorder

作　　者：郑庆梅 李耀东 卢迟英 赵小明 

机构地区：[1]佛山市顺德区伍仲佩纪念医院,广东佛山528300

出　　处：《临床心身疾病杂志》2015年第2期25-27,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的：探讨托莫西汀与哌甲酯缓释片治疗注意缺陷多动障碍患儿的临床疗效和安全性。方法将48例注意缺陷多动障碍患儿随机分为两组，每组24例，研究组口服托莫西汀治疗，对照组口服哌甲酯缓释片治疗，观察8周。治疗前后采用Conners儿童行为问卷，数字划销测验评定临床疗效，随时记录治疗过程中出现的不良反应。结果治疗后两组Conners儿童行为问卷评分学习问题、冲动‐多动、多动指数3个因子分及数字划销测验失误率较治疗前显著下降（P＜0.05或0.01），治疗第4周、8周末两组有效率比较差异无显著性（P＞0.05）。两组不良反应均较轻微，研究组主要表现为食欲下降、头晕、日间困倦、体质量下降等，对照组主要表现为食欲下降、体质量下降、头痛及入睡困难等。结论托莫西汀与哌甲酯缓释片治疗注意缺陷多动障碍患儿疗效显著，总体疗效相当，安全性高，依从性好。Objective Objective To explore the efficacy and safety of atomoxetine and methylphenidate sustained release （SR） tablets in childhood attention deficit hyperactivity disorder （ADHD） .Methods Forty‐eight ADHD children were randomly assigned to two groups of 24 ones each ,research group took o‐rally atomoxetine and control group did methylphenidate SR tablets for 8 weeks .Efficacies were assessed with the Child Behavior Rating Scale （CBRS） and Number Cancellation Test （NCT ） before and after treat‐ment and adverse reactions during treatment recorded at any time . Results After treatment learning problem ,impulsion‐hyperactivity and hyperactivity score of CBRS and the error rate of the NCT in both groups lowered more significantly compared with pretreatment （P〈0.05 or 0.01） ,there were no signifi‐cant group differences in effective rates at the end of the 4th and 8th week （P〉0.05） .Adverse reactions of both groups were mild ,they were mainly anorexia ,dizziness ,day drowsiness ,weight loss etc .in research group and anorexia ,weight loss ,headache ,difficulty falling asleep etc .in control group .Conclusion Both tomoxetine and methylphenidate SR tablets have an evident effect on childhood ADHD ,their total ef‐ficacies are equivalent ,both have higher safety and better compliance .

关 键 词：注意缺陷多动障碍 托莫西汀 哌甲酯缓释片 中枢兴奋剂 非中枢兴奋剂 Conners儿童行为问卷 数字划销测验 

分 类 号：R749[医药卫生—神经病学与精神病学]