首发精神分裂症患者及其一级亲属返回抑制对照研究  

A control study of inhibition of return of first-episode schizo-phrenia patients and their first-degree relatives

作　　者：王宝仙[1] 于晶妮 张艳[1] 安震[1] 柴萌[1] 

机构地区：[1]天津市公安局安康医院,中国天津300240

出　　处：《临床心身疾病杂志》2015年第2期72-74,共3页Journal of Clinical Psychosomatic Diseases

基　　金：天津市公安局科学技术委员会科研基金资助课题（编号2013kysaky036）

摘　　要：目的：探讨首发精神分裂症患者及其一级亲属注意返回抑制特点。方法将31例首发精神分裂症患者设为患者组，29名健康一级亲属设为亲属组，30名健康志愿者设为对照组。分别对3组被试进行注意返回抑制测试。结果3组不同线索开始呈现到靶子的时间间隔水平靶子同侧反应时间均显著长于异侧反应时间（P＜0．01），均存在返回抑制；3组所有线索开始呈现到靶子的时间间隔水平靶子同侧与异侧反应时间依次为：患者组＞亲属组＞对照组。结论首发精神分裂症患者及其一级亲属存在返回抑制功能障碍，这可能是精神分裂症的遗传易感性指标。Objective To explore attention recurrent inhibition characteristics of first‐episode schizophrenia patients and their first‐degree relatives . Methods Thirty‐one first‐episode schizophrenics were assigned to patient group ,29 healthy first‐degree relatives to relative group ,and 30 healthy volunteers to control group .Attention inhibition of return （IOR） tests were conducted among 3 groups .Results Reaction times of 3 groups at different SOA levels on the same side were significantly longer than those on the opposite side （P〈0 .01） and all had inhibition of return ;reaction times on the same and opposite side of 3 groups at all SOA levels were in turn ：patient〉relative〉control group .Con‐clusion First‐episode schizophrenia patients and their first‐degree relatives have IOR dysfunction .IOR dysfunction may be genetic susceptibility index of schizophrenia .

关 键 词：精神分裂症 亲属 返回抑制 认知功能 精神活动 神经功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]