精神分裂症患者改良电休克治疗前后血清胶质源性神经营养因子水平的变化  

Effect of modified electroconvulsive therapy on serum glial derived neurotrophic factor in schizophrenic patients

作　　者：肖文焕[1] 李金[1] 张晓斌[1] 唐小伟[1] 董慧[1] 沙维伟[1] 

机构地区：[1]扬州大学医学院附属五台山医院,225009

出　　处：《临床精神医学杂志》2015年第2期117-118,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨改良电休克治疗(MECT)对精神分裂症(SZ)患者血清胶质源性神经营养因子(GDNF)水平的影响。方法:采用酶联免疫吸附法,对48名正常人(对照组)和70例SZ患者(患者组)在MECT前后进行血清GDNF水平检测。结果:MECT前,患者组血清GDNF水平[(34.98±20.36)ng/ml]显著低于对照组[(78.23±40.57)ng/ml](t=6.821,P<0.001)。MECT后,患者组血清GDNF水平[(79.88±36.10)ng/ml]显著升高,与MECT前比较有显著差异(t=-10.64,P<0.01),与对照组差异无统计学意义(t=-0.232,P>0.05)。结论:SZ患者可能存在血清GDNF水平低下,MECT可能通过提高GDNF水平起作用。Objective： To explore the effect of modified electroconvulsive therapy（ MECT） on serum glial derived neurotrophic factor（ GDNF） in schizophrenic patients（ SZ）. Method： The serum GDNF levels were measured by enzyme-linked immunosorbent assay in 70 SZ patients（ patient group） before and after MECT and 48 normal controls（ normal group）. Results： Before MECT,the serum GDNF levels in patient group[（ 34. 98 ± 20. 36） ng/ml]were significantly lower than the levels in normal group [（ 78. 23 ± 40. 57） ng/ml,t = 6. 821,P〈0. 001]. After MECT,the serum GDNF levels were significantly increased compared to before MECT in patient group [（ 79. 88 ± 36. 10） ng / ml,t =- 10. 64,P〈0. 01]. Moreover,there was no significant difference between the patient group and normal group after MECT（ t =- 0. 232,P〉0. 05）. Conclusion：The SZ patients maybe have lower GDNF levels and MECT can increase the serum GDNF concentrations.

关 键 词：精神分裂症 改良无抽搐电休克治疗 胶质源性神经营养因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]