改良电休克治疗对精神分裂症患者视觉P300影响  

Effect of modified electroconvulsive therapy on visual P300 in patients with schizophrenia

作　　者：杜保伦 邱亚峰 陈海军 

机构地区：[1]河南省南阳市第四人民医院,473058

出　　处：《临床精神医学杂志》2015年第2期119-122,共4页Journal of Clinical Psychiatry

摘　　要：目的:观察改良电休克治疗(MECT)对精神分裂症患者前后视觉P300的变化,探讨MECT对精神分裂症患者的认知功能的影响。方法:选择80例精神分裂症患者入MECT组,单纯药物治疗者80例纳入药物组,另选医院职工20例作为正常对照组,所有研究对象均在治疗前进行1次P300检查,MECT组及药物组治疗1、4、8周后再次进行P300检查。结果:治疗前同正常对照组比较,MECT组与药物组均表现出视觉P300潜伏期显著延长(P<0.05),波幅明显降低(P<0.05),MECT组同药物组之间差异无统计学意义(P>0.05)。MECT组治疗后1周P300潜伏期、波幅、BPRS总分、焦虑抑郁、思维障碍及激活因子分较治疗前显著性改善(P<0.05)。药物组治疗1周各监测指标与治疗前差异无统计学意义,治疗4周后一些指标才出现差异。治疗8周MECT组与药物组BPRS总分及各因子分与治疗前差值差异无统计学意义。治疗8周后,MECT组与药物组总有效率差异无统计学意义(90.0%和83.8%,χ2=1.37,P>0.05)。结论:MECT控制精神分裂症症状较单纯使用药物治疗起效快,并可能对部分认知功能有改善作用。Objective： To observe the effect of modified electroconvulsive therapy（ MECT） on the change of the visual P300 and to investigate the effects of MECT on cognitive function in schizophrenia patients.Method： Eighty patients with schizophrenia was in the MECT group,80 cases with simple use drugs treatment were in the drug group and 20 healthy hospital staff members were in normal control group. P300 examination was used in all groups before treatment,and after 1,4,8 weeks treatment in MECT group and drug group.Results： Before treatment,MECT and drug group showed significantly prolonged visual P300 latencie（ P〈0. 05） and decreased amplitude（ P〈0. 05） compared with the normal control group,but no significant difference was showed between the MECT and the drug group（ P〉0. 05）. One week after treatment,P300 latency,amplitude,BPRS total score,anxiety and depression,thought disorder and activation factor scores were significantly improved in MECT group（ P〈0. 05）. Drug group showed no significant difference after 1 week treatment,but some monitoring index showed significant difference after 4 week treatment. After 8 weeks treatment,MECT group and drug group showed no significant difference between before and after treatment on BPRS total score and each factor score. After 8 weeks of treatment,MECT group and the drug group showed no significant difference on the total effective rate of（ 90% vs 83. 8%,χ2= 1. 37,P〉0. 05）. Conclusion： MECT and drug therapy can improve psychotic symptoms sooner than drug therapy only,and also improve the partial cognition function.

关 键 词：改良电休克 精神分裂症 视觉P300 认知 

分 类 号：R749.054[医药卫生—神经病学与精神病学]