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机构地区:[1]中国气象局医院中药房,北京100081 [2]北京中医药大学中药学院,100102
出 处:《国际中医中药杂志》2015年第4期349-352,共4页International Journal of Traditional Chinese Medicine
摘 要:目的:基于中医传承辅助系统软件,分析各医家治疗荨麻疹的用药经验。方法收集《实用中医美容金方》《皮肤病名家验案精选》《古今名医临证实录丛书之皮肤病》中治疗荨麻疹的病案,采用关联规则apriori算法、复杂系统熵聚类等无监督数据挖掘方法,分析处方中药物的使用频次及药物之间的关联规则、处方规律。结果对筛选出来的138首处方进行分析,处方中218味药物的使用频次在20次以上者有20味,其中防风的使用频次最高。按照药物组合出现频次由高到低的顺序,药物间的关联规则排在前4位的分别是“防风-蝉蜕”“防风-荆芥”“防风-赤芍”“荆芥-蝉蜕”,同时挖掘出30个核心药物组合和14首新处方。结论基于中医传承辅助系统平台开展的中药治疗荨麻疹的数据挖掘和用药规律研究,既为临床治疗荨麻疹提供了有效指导,同时也为治疗荨麻疹的新药研发提供依据。Objective A traditional Chinese medicine (TCM) inheritance assist system software was used to analyze the medication experiences of treating urticaria.Methods Literatures in three TCM medical books about the treatment of urticaria were collected and analyzed in terms of the utilizing frequency and association rules between different medicines. Data mining research methods such as Apriori algorithm, complex system entropy cluster and unsupervised hierarchical cluster were used in the research.Results Based on 138 screened prescriptions, the study confirmed that the frequency of using Radix sileriswas was highest, and 20 drugs elected in 218 prescription drugs were used more than 20 times. According to the utilizing frequency order of pharmaceutical compositions from high to low, association rules between drugs ranked in the top four were‘ Radix sileris- Cicada slough’, ‘Radix sileris- Schizonepeta’, ‘Radix sileris- Paeonia’, and ‘Schizonepeta- Cicadaslough’. Meanwhile, 30 pharmaceutical drug combinations and 14 new prescriptions were found. Conclusion The research, based on TCM inheritance assist system software platform and data mining method on medication rules of urticaria treatment prescriptions, is instructive in the clinical treatment of urticaria and also provide useful reference for the development of the new drug on urticaria.
分 类 号:R275.9[医药卫生—中西医结合] R249[医药卫生—中医皮科]
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