甲硫腺苷磷酸化酶基因多态性与汉族人缺血性脑卒中的关系  

THE ASSOCIATION BETWEEN MTAP GENE POLYMORPHISMS AND ISCHEMIC STROKE IN CHINESE HANS POPULATION

作　　者：李映雪[1] 李永秋[1] 王拥军[2] 

机构地区：[1]河北联合大学附属唐山市工人医院神经内科,河北省唐山市063000 [2]首都医科大学附属北京天坛医院神经内科

出　　处：《中国煤炭工业医学杂志》2015年第3期345-348,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省自然科学基金(编号:C2011105003)

摘　　要：目的研究甲硫腺苷磷酸化酶(MTAP)基因rs10118757和rs7027989位点与中国汉族人缺血性脑卒中(IS)的相关性。方法入选297例大动脉粥样硬化性IS的患者作为IS组及313例同期该院体检的汉族健康人群作为对照组。应用PCR及SNP stream技术对MTAP基因中的rs10118757和rs7027989位点进行基因分型及分析。结果在总体样本及以性别分层后的样本,rs10118757和rs7027989位点的GG基因型和G等位基因在IS组的分布频率高于对照组,但差异无统计学意义(P均>0.05)。结论 MTAP基因与汉族人大动脉粥样硬化型IS无相关。Objective To explore the association of 10118757 and rs7027989 polymorphisms in methylthioadenosine phosphorylase （MTAP} gene and ischemic stroke（IS） in Chinese Han. Methods Totally 297 large vessel IS patients and 313 healthy control subjects were enrolled into this study. Genotyping 10118757 and rs7027989 in MTAP gene were performed by using the SNP- stream genotyping platform. Results In the total sample, there was no significant difference in the distribution of genotype and allele of 10118757 and rs7027989 loci. Any significant difference was not found after the sample stratified by gender. Conclusion There is no association between MTAP gene polymorphisms and IS in Chinese Han.

关 键 词：遗传 单核苷酸多态性 甲硫腺苷磷酸化酶 缺血性脑卒中 汉族 

分 类 号：R743[医药卫生—神经病学与精神病学]