足叶乙甙联合奈达铂治疗小细胞肺癌的临床观察  

Nucleoside combined with nedaplatin in treatment of small cell lung cancer

作　　者：兰四友[1] 张德芬[2] 邓述恺[1] 王荣丽[1] 杨小琼[1] 

机构地区：[1]泸州医学院附属医院呼吸内一科,四川泸州646000 [2]泸州医学院附属医院急诊科,四川泸州646000

出　　处：《中国现代医学杂志》2015年第8期51-54,共4页China Journal of Modern Medicine

基　　金：四川省泸州医学院附属医院青年基金(No:2011-43)

摘　　要：目的观察足叶乙甙(VP-16)联合奈达铂(NDP)治疗小细胞肺癌(SCLC)的临床疗效和安全性。方法80例SCLC患者随机分为治疗组和对照组,每组40例。治疗组采用VP-16联合NDP方案;对照组采用VP-16联合顺铂(DDP)方案。21 d为1周期,治疗2周期后全面评价治疗效果,比较两组患者的临床疗效及不良反应。结果治疗组和对照组的客观缓解率(ORR)分别为77.5%和72.5%(P=0.46);中位无进展生存期(PFS)分别为9.8和7.9个月(P>0.05);1年生存率分别为68.6%和65.7%(P>0.05)。治疗组胃肠道不良反应(呕吐、恶心)和血小板减少的发生率显著低于对照组(P<0.05),两组患者其他不良反应的发生率相比差异无统计学意义。结论 VP-16联合NDP与VP-16联合DDP治疗SCLC的临床疗效相似,效果较好,并且VP-16联合NDP方案的毒副反应较小。[Objective] To observe the efficacy and the side-effects of nucleoside （VP-16） combined with nedaplatin （NDP） in the treatment of small cell lung cancer （SCLC）. [Methods] Totally 80 patients with SCLC were selected and randomly divided into observation group and control group, each group included 40 cases. The patients in the observation group were treated with VP-16 and nedaplatin while the patients in the control group were treated with VP-16 and cisplatin for 21 days as a course. After treated for two courses, the patients were examined with CT, B-mode ultrasonography and other relative test, and the therapeutic effect and adverse effects were compared between both groups. [Results] The objective response rates （ORR） were 77.5% and 72.5% in the observation group and the control group, respectively （P= 0.46）. The median progression free survivals （PFS） were 9.8 and 7.9 months, respectively （P〉 0.05）, and one-year survival rates were 68.6% and 65.7%, respectively （P〉 0.05）. The incidences of gastrointestinal reactions and thrombocytopenia in the observation group were significantly lower than those in the control group （P〈 0.05）. No significant difference was observed in the incidences of other adverse effects between the two groups. [ Conclusions] Nucleoside plus nedaplatin is an effective treatment with less side-effects.

关 键 词：足叶乙甙 奈达铂 小细胞肺癌 化疗 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]