急性缺血性脑卒中患者血清ApoB/ApoA1与NIHSS评分的相关性  

Correlation between ApoB/ApoA1 ratio and NIHSS score in patients with acute ischemic stroke

作　　者：李旭[1] 张飚[1] 曹沁梅 

机构地区：[1]天津市环湖医院,天津300060 [2]卫生部中日友好医院

出　　处：《山东医药》2015年第10期11-13,共3页Shandong Medical Journal

基　　金：天津市卫生局科技基金资助项目(2011KR08)

摘　　要：目的探讨血清载脂蛋白B（Apo B）与载脂蛋白A1（Apo A1）比值Apo B/Apo A1在急性缺血性脑卒中患者病情判断中的价值。方法研究对象为191例缺血性脑卒中急性发作患者,美国国立卫生研究院卒中量表（NIHSS）评分≤6分71例（低评分组）、7-14分58例（中评分组）、≥15分62例（高评分组）。各组均于入院后空腹采集静脉血,检测血清TG、TC、Apo B、Apo A1水平,计算Apo B/Apo A1。分析TC、TG、Apo B/Apo A1与NIHSS评分的相关性。结果 Apo B/Apo A1：高评分组〉中评分组〉低评分组（P均〈0.05）。高评分组血清TG水平低于低评分组（P〈0.05）。Apo B/Apo A1与NIHSS评分呈正相关（r=0.242,P〈0.05）,TG与NIHSS评分呈负相关（r=-0.220,P〈0.05）,TC与NIHSS评分无相关性（r=0.136,P〉0.05）。结论 Apo B/Apo A1是反映缺血性脑卒中患者病情严重程度的较好指标。Objective To investigate the value of serum apolipoprotein B （ApoB）/apolipoprotein A1 （ApoA1） ratio in judging the condition of acute ischemic stroke .Methods A total of 191 cases of patients with acute ischemic stroke were studied, whose NIHSS score ≤6 was the low group （71 cases）, NIHSS score ≤14 and ≥7 was the medium group （58 cases） and NIHSS score ≥15 was the high group （62 cases）.After admission, the venous blood of patients in all groups was collected with empty stomach .The levels of TG, TC, ApoB and ApoA1 were measured and ApoB/ApoA1 was calculated in every group .The correlations between TG , TC, ApoB/ApoA1 and NIHSS score were analyzed .Results Comparison of ApoB/ApoA1 in three groups：high group 〉medium group 〉low group （all P〈0.05）.TG：high group〈low group （P〈0.05）.ApoB/ApoA1 was positively correlated with NIHSS score （r=0.242,P〈0.05）.TG was nega-tively correlated with NIHSS score （r=-0.220,P〈0.05）.TC was not related to NIHSS score （r=0.136,P〉0.05）. Conclusion ApoB/ApoA1 is a better indicator to determine the severity of ischemic stroke .

关 键 词：缺血性脑卒中 载脂蛋白B 载脂蛋白A1 血脂 

分 类 号：R743.3[医药卫生—神经病学与精神病学]