齐墩果酸、肝泰乐预防抗结核药致肝损害的效果  

Efficacy observation on the preventive role of Oleanolic acid and Glucurolactone in antituberculous medicament-induced hepatic damage

作　　者：田磊[1] 白敏[1] 杨令果[1] 

机构地区：[1]91医院传染结核科,山东兖州272100

出　　处：《实用医药杂志》2002年第7期495-496,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的评价齐墩果酸、肝泰乐对抗结核药物引起肝损害的预防效果。方法382例结核病患者随机分为观察组与对照组,均应用含“HRZ”的方案抗结核化疗,观察组同时加用齐墩果酸、肝泰乐。结果药物性肝损害发生率观察组为3.6%,显著低于对照组的8%(P<0.05);中断或重新调整结核化疗的发生率,观察组无1例发生,对照组为2.6%,两组比较差异非常显著(P<0.01);肝损害发生时间均在服药7～90d,两组间无显著性差异(P>0.05)。结论齐墩果酸、肝泰乐可显著降低抗结核药对肝的损害,减少或避免因结核性药物肝损害所致的不规律化疗。Objective To evaluate the preventive efficacy of Oleanolic acid and Glucurolactone on the medicamentous liver lesion caused by antituberculosis medicament.Methods The382TB patients were randomly separated into two groups:control group and study group.Both groups were treated using the'HRZ″protocols,which is a kind of antituberculosis chemotherapy.But the patients of the study group also took Glucurolactone and Oleanolic acid tablets.Results The incidence rate of medicamentous liver lesion in the study group,3.6%,significantly(P<0.05)different from the rate in control group,8%;no case in the study group occurred to stop or adjust the medicamentous treatment,but in the control group the rate was2.6%,indicating a significant difference(P<0.01);liver lesion happened from the first week to the third month in both groups(P>0.05).Conclusion Oleanolic acid and Glucurola ctone can obviously decrease the rate of medicamentous liver lesion,and decrease or prevent the irregular chemotherapy that results from the liver lesion caused by antituberculosis medicament

关 键 词：药物性肝损害 临床研究 齐墩果酸 肝泰乐 预防 抗结核药 

分 类 号：R575[医药卫生—消化系统] R978.3[医药卫生—内科学]