VEGF-2578C>A基因多态性与肺癌发病关联性的Meta分析  

Meta-analysis of correlation between VEGF-2578C>A gene polymorphism and lung cancer risk

作　　者：李莹[1] 苏勇[1] 张亚峰[1] 孙桂香[1] 

机构地区：[1]徐州医学院公共卫生学院,江苏徐州221004

出　　处：《中国校医》2015年第3期222-224,226,共4页Chinese Journal of School Doctor

摘　　要：目的 Meta分析方法探讨血管内皮生长因子（VEGF）-2578C〉A基因多态性与肺癌发病的相关性。方法检索CBM、CNKI和Pub Med数据库,收集国内外从建库到2013年11月公开发表的关于肺癌与VEGF-2578C〉A关联研究的文献,应用Rev Man5.0分析软件进行Meta分析。结果最终纳入病例对照研究7篇,包含肺癌组1657例和健康对照组1716例。结果显示：在等位基因模型（OR=1.29,95%CI=1.15-1.45,P〈0.0001）;隐性模型（OR=1.85,95%CI=1.36-2.53,P=0.0001）;纯合子模型（OR=2.04,95%CI=1.48-2.80,P〈0.0001）;杂合子模型（OR=0.53,95%CI=0.30-0.92,P=0.02）中,VEGF-2578C〉A基因多态性与肺癌发病相关具有统计学意义。敏感性分析提示结论稳定性好。结论 VEGF-2578C〉A单核苷酸基因多态性与肺癌发病风险相关,携带A等位基因的基因型（CA＋AA）可以显著增加肺癌的发病风险。Objective To assess the correlation between VEGF-2578C〉A gene polymorphism and lung cancer risk in Chinese population by meta-analysis method. Methods The articles about the relationship between lung cancer and VEGF-2578C/A were collected from Chinese Biomedical Literature Database on disc （CBM-disc）, CNKI and Medline databases and all the relevant results were analyzed by RevMan 5.0 software. Results A total of 1 657 patients with lung cancer and 1 716 uninfected healthy controls were included from 7 studies. The Meta-analysis results showed that a statistically significant correlation was found between VEGF-2578C〉A polymorphism and lung cancer risk in Chinese popnlation under allele, recessive, homozygous and homozygous models （for OR=1.29, 95%CI=1.15-1.45, P〈0.000 1; 0R=1.85, 95%CI=1.36-2.53, P=-0.000 1; OR=2.04, 95%CI=1.48-2.80, P〈0.000 1; OR=0.53, 95%CI=0.30-0.92, P=0.02）. The results of sensitivity analysis indicated that the conclusion was stable and reliable. Conclusion The lung cancer risk is associated with the gene polymorphism of VEGF-2578C〉A in Chinese population and carrying A allele （CA ＋ AA） may significantly increase the lung cancer risk.

关 键 词：肺肿瘤/遗传学 血管内皮生长因子A/遗传学 单核苷酸 META分析 

分 类 号：R734[医药卫生—肿瘤]