巨噬细胞极化及牙龈卟啉单胞菌对其极化调控的研究进展  

The Research Progress in Polarization of Macrophage and the Effect of Porphyromonas Gingivalis on the Macrophage Polarization

作　　者：于海燕[1,2] 高爱超[1,2] 李娜[1,2] 于维先[1,2] 

机构地区：[1]吉林大学口腔医学院牙发育及颌骨重塑与再生省重点实验室,长春130021 [2]吉林大学口腔医院牙周病科,长春130021

出　　处：《医学综述》2015年第7期1187-1189,共3页Medical Recapitulate

基　　金：吉林省自然科学基金(201115104)

摘　　要：牙龈卟啉单胞菌(Pg)是慢性牙周炎的重要病原菌,其毒力部分来自细菌细胞壁及产物,如脂多糖、菌毛、荚膜多糖和牙龈蛋白酶。这些化学成分在诱导宿主先天和后天的免疫反应中起重要的作用,如诱导巨噬细胞的极化和炎性细胞因子的释放。极化的巨噬细胞对炎症的进展、组织的破坏和炎症的抑制、损伤组织的修复与重建等具有重要作用。该文就巨噬细胞的极化特点以及Pg对巨噬细胞极化的影响进行综述,为牙周病的防治寻找新的途径。Porphyromonas gingivalis（Pg） is an important pathogen of chronic periodontitis,and cell wall and products of the bacterium,such as lipopolysaccharides,fimbriae,capsule polysaccharide and gingipains are the virulence factors.These factors play an important role in the induction of innate and acquired immune response,such as the polarization of macrophages and the release of inflammatory cytokines.Polarized macrophages play an important role in the progress of inflammation,tissue damage,inhibition of inflammation,restoration and reconstruction of damaged tissue.So in order to find a new way for the treatment of periodontitis,here is to make a review of the polarization characteristics of macrophage and the effect of Pg on the macrophage polarization.

关 键 词：巨噬细胞 极化 牙龈卟啉单胞菌 

分 类 号：R781.4[医药卫生—口腔医学] R392[医药卫生—临床医学]