PEI联合HIFU治疗不能手术切除的中晚期原发性肝癌的临床研究  

Clinical study of PEI combined with HIFU for treating unresectable middle and advanced stages of primary liver cancer

作　　者：吴光平 蒲元芳 田阗 庞勇 曹轲 杨咏 徐波 李媛 谢艳 何敏[2] 

机构地区：[1]重庆市南川区人民医院妇科海扶治疗中心,重庆南川408400 [2]重庆医科大学生物医学工程学院,重庆400016

出　　处：《重庆医学》2015年第10期1367-1369,共3页Chongqing medicine

摘　　要：目的探讨在镇静镇痛下行无水乙醇注射术(PEI),能否提高高强度聚焦超声(HIFU)治疗不能手术切除的中晚期原发性肝癌(PCL)的能量沉积及其治疗效率。方法将临床确诊的不能手术切除的中晚期PCL患者36例分为PEI联合HIFU治疗组(联合组,n=23)和单纯HIFU治疗组(HIFU组,n=13);联合组于消融前30min向瘤体内注入99.70%无水乙醇与碘化油(9∶1)混合液10mL,HIFU组以0.9%生理盐水10mL替代,比较两组患者消融的能效因子(EEF)及辐照时间。结果联合组、HIFU组消融EEF分别为(13.82±4.26)、(25.63±6.31)J/mm3,联合组明显低于HIFU组(P<0.05);辐照时间分别为(1 468.28±253.21)、(2 352.56±463.34)s;联合组辐照时间明显缩短(P<0.05)。结论 PEI能够增强HIFU消融能量沉积,能够提高HIFU治疗不能手术切除的PCL的治疗效率。Objective To investigate whether the percutaneous ethanol injection（PEI）under sedation and analgesia can increase the energy deposition and curative efficiency of the high intensity focused ultrsound（HIFU）in treating unresectable middle and advanced stages of primary liver cancer.Methods Thirty-six cases of clinically diagnosed unresectable middle and advanced stages of primary liver cancer were randomly divided into the PEI＋HIFU group（combination group,n=23）and the simple HIFU group（HIFU group,n=13）;10mL of the mixture of 99.7%ethanol and iodized oil（9：1）was given by intratumoral injection at 30 min before ablation in the PEI＋HIFU group,while 0.9% physiological saline 10 mL was replaced in the simple HIFU group.The ablation energy efficiency factor（EEF）and irradiation time were compared between the two groups.Results The ablation EEF in the PEI＋HIFU group and the simple HIFU group were（13.82＋4.26）J/mm^3 and（25.63＋6.31）J/mm^3 respectively,the PEI＋HIFU group was significantly lower than the simple HIFU group（P〈0.05）;the irradiation time were（1 468.28＋253.21）s and（2 352.56＋463.34）s respectively;which in the PEI＋HIFU group was significantly shortened（P〈0.05）.Conclusion PEI can enhance the HIFU ablation energy deposition and improve the efficiency of HIFU for treating unresectable primary liver cancer.

关 键 词：超声 高强聚焦 经肠 肝肿瘤 能效因子 无水乙醇注射术 

分 类 号：R735.7[医药卫生—肿瘤]