羟考酮缓释片联合吗啡片在癌痛滴定治疗中的应用  

Application of Controlled-release Oxycodone and Oral Immediate-release Morphine in the Titration Treatment of Cancer Pain

作　　者：吴海霞[1] 陈燕平[1] 沈齐[1] 曹雪[1] 鲁亮[1] 

机构地区：[1]贵州省人民医院肿瘤科,贵州贵阳550002

出　　处：《肿瘤药学》2015年第2期112-115,共4页Anti-Tumor Pharmacy

摘　　要：目的观察盐酸羟考酮缓释片(奥施康定)联合吗啡片在中、重度癌痛治疗中的镇痛效果及不良反应。方法选择112例中重度癌痛患者,随机分为吗啡组50例(给予吗啡即释片镇痛)和联合组62例(给予羟考酮缓释片联合吗啡片镇痛)。对两组的镇痛疗效、起效时间及不良反应进行观察及评估。结果与吗啡组比较,联合组的滴定剂量降低,镇痛起效时间明显缩短,差异具有统计学意义(P<0.05);联合组便秘及恶心呕吐的发生率均明显低于吗啡组,差异具有统计学意义(P<0.05)。结论羟考酮缓释片联合吗啡片滴定方案治疗中、重度癌痛起效快、镇痛效果好,副反应轻,是治疗癌痛较好的选择之一。Objective To observe the analgesic effects and main side effects of controlled-release oxycodone（oxycontin） and oral immediate-release morphine in the treatment of moderate and severe cancer pain. Methods A total of 112 patients with severe cancer pain were divided into morphine group in which immediate-release morphine is involved with 50 cases, and combined group in which oxycodone sustained-release tablets combined with morphine tablets with 62 cases. Therapeutic effects and time to onset and adverse reaction was compared between the two groups. Results Compared with the morphine group, the titration dose of the combined group decreased, and the analgesic onset time was shortened obviously, with statistic difference（P〈0.05）. The incidence of constipation and nausea and vomiting in the combination group were significantly lower than that of morphine group, also with significant difference（P〈0.05）. Conclusion The dosage titration therapy with combination of controlled-release oxycodone and oral immediate-release morphine worked quickly, safely and effectively on moderate and severe cancer pain, and had comparatively slight side effects. It is a good choice for cancer pain.

关 键 词：癌痛 羟考酮缓释片 吗啡片 滴定治疗 

分 类 号：R730.6[医药卫生—肿瘤]