紫杉醇脂质体与顺铂周疗方案同步放疗治疗中晚期宫颈癌的疗效比较  

Comparison of the Efficacy of Weekly Paclitaxel Liposome and Cisplatin Chemotherapy Plus Concurrent Radiotherapy in the Treatment of Middle and Advanced Cervical Cancer

作　　者：曹珍珍[1] 唐迪红[1] 夏蛮[1] 禇超男 蔡净亭[1] 杨婷[1] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院妇瘤四科,湖南长沙410006

出　　处：《肿瘤药学》2015年第2期116-119,共4页Anti-Tumor Pharmacy

摘　　要：目的探讨紫杉醇脂质体与顺铂周疗方案同步放疗治疗中晚期宫颈癌的临床疗效。方法抽取2013年9月~2014年9月于我院就诊的中晚期宫颈癌患者共86例,随机分为实验组与对照组,实验组（n=43）予以紫杉醇脂质体周疗（90 mg·m-2）联合放疗,共4~6周。对照组（n=43）予以顺铂周疗（40 mg·m-2）联合放疗,共4~6周。观察和比较两组患者的治疗效果和不良反应的发生情况。结果实验组治疗总有效率为90.1%,对照组为93.0%,两组比较差异无统计学意义（P〉0.05）;实验组白细胞减少、血小板降低、恶心呕吐和脱发的发生率较对照组显著降低（P〈0.05）,但两组腹泻和肝肾损害的发生率比较,差异无统计学意义（P〉0.05）。结论紫杉醇脂质体与顺铂周疗方案同步放化疗治疗中晚期宫颈癌的临床效果相当,但紫杉醇脂质体周疗同步放化疗的安全性更高。Objective To investigate the clinical efficacy and safety of weekly paclitaxel liposome and cisplatin chemotherapy plus concurrent radiotherapy in the treatment of middle and advanced cervical cancer. Methods From September 2013 to September 2014, 86 patients with middle and advanced cervical cancer who received concurrent chemoradiotherapy in our hospital were selected. All cases were divided into experimental group and control group according to different chemotherapy regimens during radiation therapy. Patients in experimental group（n=43） received radiotherapy concomitant with weekly paclitaxel liposome（90 mg·m-2） for 4-6 weeks, while those in control group（n=43） received radiotherapy concomitant with cisplatin（90 mg·m-2） for 4-6 weeks. The clinical efficacy and incidence of adverse reactions were observed and compared between two groups. Results The effective rates were respectively 90.1% and 93% in experimental group and control group, and there was no significant difference（P〈0.05）. The incidence of leucopenia, nausea vomit, thrombocytopenia and calvities in experimental group were significantly higher than those in the control group（P〈0.05）. However, no significant differences were found in the occurrence rates of diarrhea and liver and renal dysfunction between two groups（P〈0.05）. Conclusions The weekly paclitaxel liposome plus concurrent radiotherapy had equal efficacy to but higher safety than the weekly cisplatin plus concurrent radiotherapy in the treatment of middle and advanced cervical cancer.

关 键 词：紫杉醇脂质体 顺铂 中晚期宫颈癌 临床疗效 

分 类 号：R737.33[医药卫生—肿瘤]