Tenascin在胶质瘤侵袭中的表达及与预后的关系  

Expression of tenascin in gliomas invasion and its relation to recurrence and prognosis

作　　者：吕学明[1] 章翔[2] 李涌[1] 马乃绪[1] 孔令学[1] 谭林琼[1] 郑鲁[1] 陈元朝[1] 吕福林[1] 

机构地区：[1]91医院,山东兖州272100 [2]第四军医大学西京医院全军神经外科研究所,陕西西安710032

出　　处：《实用医药杂志》2002年第7期524-527,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨胶质瘤侵袭性生长Tenascin的表达,评估Tenascin及微血管形成密度(microvesseldensity)MVD与胶质瘤预后的相关性。方法应用免疫组织化学方法对35例不同病理级别人脑胶质瘤组织中tenascin及CD34表达进行观察,并对患者进行术后随访观察。结果不同病理级别的胶质瘤胞浆内Tenascin表达程度和MVD差异明显,Tenascin表达和MVD有相关性(P<0.01)。Kaplan-Meier生存曲线表明,Tenascin表达及MVD与胶质瘤的预后有关。结论Tenascin在胶质瘤侵袭性生长、转移等方面是至关重要的,Tenascin和MVD促进胶质瘤侵袭性生长并对判断患者预后有重要参考价值。Objective To explore the expression of tenascin in human gliomas invasion,and to evaluate the relation of tenascin and MVD(microvessel density)in glioma s with prognosis.Methods The expression of tenascin and CD34in35patients in different stage was determined by immunohistochemistry,and the patients were followed up after operation.Results The expression of tenascin and MVD varied with tumor cell differentiation and tumor stage,the differences were significant.The expression of tenascin is closely associated with angiogenesis (P<0.01).Kaplan-Meier survival curve showed that both MVD and tenascin expression were associated with prognosis.Conclusion Tenascin is very important in gliomas invasion and metastasis.Tenascin and MVD can promote gliomas invasion,and they should be used to determine the patients' prognosis

关 键 词：胶质瘤 TENASCIN 微血管密度 预后 免疫组织化学 细胞间粘附抑制因子 

分 类 号：R739.41[医药卫生—肿瘤]