紫杉醇和顺铂新辅助化疗对局部晚期鼻咽癌疗效分析  

The curative effect analysis of new adjuvant chemotherapy with paclitaxel and cisplatin on locally advanced nasopharyngeal carcinoma

作　　者：王美江[1] 罗德红[1] 付斯瑜[1] 陈奕霖[1] 

机构地区：[1]遵义市第一人民医院肿瘤科,贵州遵义133012

出　　处：《黑龙江医药科学》2015年第2期83-84,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:分析治疗局部晚期鼻咽癌,采用紫杉醇和顺铂新辅助化疗的效果。方法:选取在我院治疗局部晚期鼻咽癌的30例患者,随机分实验组和对照组,实验组:紫杉醇加顺铂同期化疗,对照组:顺铂加尿嘧啶同期放疗,两组放疗方法、剂量照射均相同。结果:两组近期疗效对比统计学无意义(P>0.05),实验组毒副反应发生率低于对照组,对比有差异,有统计学意义(P<0.05)。结论:紫杉醇和顺铂新辅助化疗,对局部晚期鼻咽癌近期疗效好,毒副反应少。Objective： To analysis the treatment of locally advanced nasopharyngeal carcinoma,and the effect of new adjuvant chemotherapy with paclitaxel and cisplatin. Methods： 30 cases of local advanced nasopharyngeal carcinoma patients treated in our hospital were selected,and randomly divided into experimental group and control group. In experimental group： paclitaxel plus cisplatin received chemotherapy. In control group： cisplatin plus uracil received radiation. The dose and method of radiation therapy in both group were the same. Results： The comparisons of the curative effect in both groups were statistically insignificant（ P 〉0. 05）. The incidence of adverse reaction was lower than that in the control group. While there were differences in contrast,which was statistically significant（ P 〈0. 05）. Conclusion： Paclitaxel and cisplatin neoadjuvant chemotherapy have good curative effect on locally advanced nasopharyngeal carcinoma,with less adverse reaction.

关 键 词：紫杉醇 顺铂 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]