序贯疗法联合口腔洁治对慢性萎缩性胃炎患者胃幽门螺杆菌根除的近期疗效研究  

Short Term Efficacy of Ten- day Standard Sequential Therapy Combined With Dental Scaling on Helicobacter Pylori Eradication in Patients With Chronic Atrophic Gastritis

作　　者：孙佩玉[1] 

机构地区：[1]浙江省嘉兴市第一医院药剂科,314000

出　　处：《中国全科医学》2015年第10期1172-1175,共4页Chinese General Practice

摘　　要：目的探讨序贯疗法联合口腔洁治对慢性萎缩性胃炎患者胃幽门螺杆菌(Hp)根除的近期疗效。方法将2013年1月—2014年1月在我院消化科门诊就诊的慢性萎缩性胃炎且胃、口腔Hp阳性患者132例作为研究对象,采用随机数字表法分为治疗组62例和对照组70例。治疗组给予10 d序贯疗法和口腔洁治法,对照组单纯给予10 d序贯疗法。比较两组治疗前、治疗后1个月、治疗后3个月的胃Hp根除率、口腔Hp阳性率及治疗前、治疗后1个月病理、症状评分。结果两组患者在序贯治疗后1个月进行胃、口腔Hp检测,结果显示:治疗组的胃Hp根除率、口腔Hp阳性率与对照组比较,差异均有统计学意义(P<0.05)。治疗前,两组的病理评分、症状评分间差异均无统计学意义(P>0.05);序贯治疗后1个月,两组的病理评分、症状评分间差异均有统计学意义(P<0.05)。两组患者在序贯治疗后3个月进行胃、口腔Hp检测,结果显示:治疗组的胃Hp根除率、口腔Hp阳性率与对照组比较,差异均有统计学意义(P<0.05)。结论序贯疗法联合口腔洁治对慢性萎缩性胃炎患者胃Hp根除效果好且安全性高。Objective To investigate the efficacy of ten- day standard sequential therapy combined with dental scaling therapy on helicobacter pylori（ Hp） in patients with chronic atrophic gastritis. Methods A total of 132 patients with chronic atrophic gastritis and positive Hp in both stomach and oral cavity were enrolled from Gastroenterology Department of the First Hospital of Jiaxing from January,2013 to January,2014 and were randomly assigned into observation group（ n = 62） and control group（ n = 70）. The observation group received ten- day standard sequential therapy combined with dental scaling therapy. The control group received ten- day standard sequential therapy only. Before treatment,one month and 3 months after treatment,two groups were compared by gastric Hp eradication rate,oral Hp positive rate and scores of pathological mechanism and symptoms. Results One month after treatment,two groups were significantly different in gastric Hp eradication rate and oral Hp positive rate（ P 0. 05）. Before treatment,two groups were not significantly different in scores of pathological mechanism and symptoms（ P 0. 05）; One month after treatment,significant differences occurred between two groups（ P 0. 05）. Three months after treatment,two groups were significantly different in gastric Hp eradication rate and oral Hp positive rate（ P 0. 05）. Conclusion Ten- day standard sequential therapy combined with dental scaling therapy has better Hp eradication effect and safety on patients with chronic atrophic gastritis.

关 键 词：幽门螺杆菌 胃炎 萎缩性 序贯疗法 口腔医疗 治疗结果 

分 类 号：R573.32[医药卫生—消化系统]