Hsa-miR-133a在非小细胞肺癌中的表达及其与临床病理联系  

The expression of Hsa-miR-133ain non-small cell lung cancer and its clinic-opathological characteristics

作　　者：王玉洲[1] 吴鲲鹏[1] 陈宝英[1] 杨志雄[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,湛江524001

出　　处：《齐齐哈尔医学院学报》2015年第9期1255-1257,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨Hsa-miR-133a在非小细胞肺癌(NSCLC)中的表达及其与NSCLC临床病理特征之间的相关性,为Hsa-miR-133a预测肺癌发生风险和进展程度提供客观依据。方法采用实时荧光定量PCR检查50例NSCLC及癌旁组织中Hsa-miR-133a表达情况;收集患者一般资料(如年龄、性别)和临床病理资料(临床分期、淋巴结转移、远处转移、病理类型、组织分化程度),通过卡方检验分析Hsa-miR-133a与NSCLC患者临床病理特征之间的相关性。结果与癌旁肺组织相比较,50例NSCLC组织中,Hsa-miR-133a表达下降(P<0.05),其表达的平均水平降低约6.571倍(P=0.000)。与不伴淋巴结转移的肺癌组织相比,伴有淋巴结转移的肺癌组织中,Hsa-miR-133a表达下降(P<0.05),其表达的平均水平降低约1.381倍(P=0.010)。Hsa-miR-133a表达情况与病理分级、临床分期和淋巴结转移有关(P<0.05),与年龄、性别、病理类型以及肿瘤大小无关(P>0.05)。结论 Hsa-miR-133a在NSCLC组织中表达下调与NSCLC淋巴结转移、远处转移和病理分期有关。Objective This article was to investigate the correlation between Hsa -miR -133a expression and clinic -pathological characteristics, which would be useful evidence to predict the progression degree of NSCLC.Methods The RT-qPCRmethod was used to measure the expression of miR-133ain non-small cell lung carcinoma tissue and pericarcinomatous tissue.The general features of patients with NSCLC（ such as age, gender） and clinic-pathological data （ such as clinical stage, lymph node metastasis, distant metastasis, pathology classification, histological differentiation ） were collected.The relationship between the expression of miR-133a and clinic-pathological characteristics was explored by Kaplan-Meier test.Results The expression of miR-133a decreased about 6.571 folds （ P=0.000） in NSCLCs compared with matched pericarcinomatous tissue.Compared with no lymph node metastasis of lung cancer, expression of miR-133a in lung cancer with lymph node metastasis decreased （P=0.010）, and lower average about 1.381 folds.The expression of miR-133a statistically associated with lymphnode metastasis, clinic stage and pathologic differentiated degree in NSCLC.Correlations of miR-133a were not observed in age, gender, pathological classification and tumor size. Conclusions Compared with pericarcinomatous tissues, the expression of miR-133a downregulated in non-small cell lung carcinoma tissue.The Expression of miR -133a was statistically associated with lymph node metastasis, clinical stage and pathologic differentiation in lung cancer.

关 键 词：miR-133a 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]