国内多奈哌齐治疗卒中后失语疗效的Meta分析  

Meta-analysis of Curative Effect in Domestic Donepezil Treating Post-stroke Aphasia

作　　者：林珍萍 陈卓铭[1] 廖成钜 杨健[1] 

机构地区：[1]暨南大学附属第一医院

出　　处：《按摩与康复医学》2015年第5期8-11,共4页Chinese Manipulation and Rehabilitation Medicine

基　　金：广州市科技计划重大民生项目,编号:2012Y2-00023

摘　　要：目的：评价多奈哌齐治疗卒中后失语的有效性。方法：计算机检索收集多奈哌齐治疗卒中后失语的已出版中英文献，并采取JADAD质量评估及Review Manager5.2软件Meta分析，对无异质性研究采用固定效应模型分析，对异质性研究采用随机效应模型分析。结果：共纳入8篇随机对照研究，分多奈哌齐组和安慰剂组，JADAD评分2~4分，Meta分析结果示失语商（Z=6.09，P〈0.00001）异质性较小且有统计学差异；口语表达（Z=3.77，P=0.0002）、听理解（Z=5.19，P〈0.00001）、复述（Z=3.82， P=0.0001）、命名（Z=2.60，P=0.009）虽有统计学意义但异质性较大。结论：多奈哌齐整体上可改善卒中后失语症状。Objective：To evaluate the efficacy of donepezil treating aphasia after stroke. Methods：To collect published Chinese and English literature about donepezil treating aphasia after stroke with computer retrieval, analyzing with JADAD quality assessment and Review Manager5.2 software, no heterogeneity study adopted fixed effect model analysis, heterogeneity study adopted random effects model analysis. Results：8 randomized con-trolled studies were included and divided into donepezil group and placebo group, JADAD score from 2 to 4, Meta-analysis showed the heterogene-ity of aphasia quotient （Z=6.09,P〈0.00001） was small and with significant difference;oral expression （Z=3.77,P=0.0002）, listening comprehension （Z=5.19,P〈0.00001）, repeat（Z=3.82,P=0.0001）, naming （Z=2.60,P=0.009） is statistically significant but largely heterogeneity. Conclusion：Donepe-zil can improve the symptoms of aphasia after stroke overall.

关 键 词：卒中后失语 多奈哌齐 疗效 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]