吉兰巴雷综合征患者急性期病情严重程度相关因素分析  

Analysis on relevant factors of severity of Guillain-Barre syndrome during acute phase

作　　者：高睿[1] 韩露[1] 管阳太[1] 

机构地区：[1]第二军医大学附属长海医院神经内科,上海200433

出　　处：《中国医药导报》2015年第11期93-96,100,共5页China Medical Herald

摘　　要：目的分析吉兰巴雷综合征（GBS）急性期临床、电生理及脑脊液特点,并探讨其病情进展严重程度的相关因素。方法回顾性分析2000年10月-2014年10月于长海医院就诊的GBS患者113例,根据患者高峰期Hughes评分划分病情等级,用Logistic回归模型分析病情严重程度与临床、电生理及脑脊液指标的相关性。结果急性期GBS患者年龄≥50岁（P=0.034,OR=14.702,95%CI：1.228-175.982）、脑脊液IgG增高（P=0.028,OR=26.652,95%CI：1.438-493.791）、周围神经轴索损害为主者（P=0.037,OR=48.529,95%CI：1.273-1850.656）更易发展为重型GBS。结论存在年龄≥50岁、脑脊液IgG增高、周围神经轴索损害的GBS患者病情相对较重,临床医生应针对此类患者提前实现个体化治疗。Objective To analyze the clinical, electrophysiological and cerebrospinal characteristics of Guillain-Barre syndrome（GBS） during acute phase, and to explore the relevant factors of severity of progressive disease. Methods 113 patients with GBS admitted to Changhai Hospital from October 2000 to October 2014 were analyzed retrospectively.Hughes scale of fastigium was used to divide the illness level. Logistic regression model was used to analyze the correlation of severty of illness with clinical, electrophysiological and cerebrospinal indexes. Results Among the patients with GBS during acute phase, those whose age≥50 years old（P = 0.034, OR = 14.702, 95%CI： 1.228-175.982）, increase of immunoglobulin G in cerebrospinal fluid（P = 0.028, OR = 26.652, 95%CI： 1.438-493.791）, peripheral nerve neuraxon impairment（P = 0.037, OR = 48.529, 95%CI： 1.273-1850.656） were more likely to develop as severe GBS.Conclusion The state of patients with age≥50 years old, increase of immunoglobulin G in cerebrospinal fluid, peripheral nerve neuraxon impairment is more severe. Clinical doctors should realize individualized treatment in advance aiming at such patients.

关 键 词：吉兰巴雷综合征 病情严重程度 相关因素 

分 类 号：R744.5[医药卫生—神经病学与精神病学]