口腔厌氧感染患者应用不同药物治疗效果比较分析  

Observation and analysis for effect of different drugs used in treatment of patients with oral anaerobic infection

作　　者：方雪峰 

机构地区：[1]广东省潮州市中医医院口腔科,521000

出　　处：《山西医药杂志》2015年第7期743-745,共3页Shanxi Medical Journal

基　　金：潮州市卫生局科研项目(101488)

摘　　要：目的比较与分析左奥硝唑氯化钠注射液与奥硝唑氯化钠注射液治疗口腔压氧菌感染者的临床疗效及安全性。方法 86例口腔厌氧菌患者按照随机抽签法分为对照组与观察组。对照组采用奥硝唑氯化钠注射液,静脉滴注,2次/d;观察组采用左奥硝唑氯化钠注射液,静脉滴注,2次/d。比较2组临床治疗效果与治疗期间所发生不良反应,同时评价2者安全性。结果治疗后,观察组治疗有效率为93%(40/43)与对照组88%(38/43)比较差异无统计学意义(P>0.05);2组厌氧菌清除率比较差异无统计学意义(P>0.05)。左奥硝唑氯化钠注射液治疗不良反应发生率小,2组患者不良反应发生率,差异有统计学意义(P<0.05)。结论相对奥硝唑氯化钠注射液来说,左奥硝唑氯化钠注射液的临床疗效及细菌清除效果与其相当,但其临床治疗过程中所发生不良反应少,因而更具有安全性。Objective To compare and analyze the clinical efficacy and safety of tinidazole and sodium chlo- ride injection and ornidazole and sodium chloride injection in the treatment of oral anaerobic bacteria infec- tion. Methods Eighty-six cases of oral anaerobic bacteria were randomly divided into control group and observa- tion group. Control group was treated with ornidazole and sodium chloride injection, intravenous infusion, 2 times/day; the observation group was treated with tinidazole and sodium chloride injection, intravenous infusion, 2 times/day. The occurrence of adverse reactions compared 2 groups of clinical curative effect during treatment pe- riod were compared between 2 groups, and safety was also evaluated. Results After treatment, the patients in the observation group the effective rate was 93 % （40/43） and 88 % in the control group （38/43） comparison （P〉0.05） ; 2 groups of anaerobic bacteria clearance rate （P〉0.05）. The incidence of adverse reaction of 2 groups of patients （ P〈0.05）. Conclusion Comared with ornidazole and sodium chloride injection, tinidazole and sodium chloride injection was of similar clinical curative effect and bacteria clearance effect, but the clinical course of treat- ment was with less adverse reactions, which is more safe.

关 键 词：口腔 细菌 厌氧 硝基咪唑类 

分 类 号：R781.05[医药卫生—口腔医学]