加巴喷丁对偏头痛患者中枢敏感化的疗效评价  

The appraisal of gabapentin on the cure of migrainal central sensitization

作　　者：张家君[1] 姜岳梅 赵晓霞[3] 牛敬忠[4] 张颜波[4] 

机构地区：[1]泰山医学院附属医院超声科,山东泰安271000 [2]山东省泰安荣军医院,山东泰安271000 [3]山西省人民医院神经内科,山西太原030012 [4]泰山医学院附属医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2014年第11期1105-1107,共3页Journal of Taishan Medical College

基　　金：山东省自然科学基金(ZR2012HQ014);泰安市科技发展计划(20123060)

摘　　要：目的观察加巴喷丁对偏头痛患者中枢敏感化的疗效。方法随机分为加巴喷丁治疗组(GBP组)和佐米曲普坦对照组,每组43例,疗程1d。采用CA症状自评量表,对治疗前(头痛发作后2h)、后进行中枢敏感化评定。结果偏头痛发病后2小时,58例出现CA,出现率为67.4%,轻、中、重CA出现率分别为24.4%、19.8%、22.8%。两组治疗后CA出现率与治疗前相比均明显下降,有统计学意义(P<0.05,P<0.01);GBP组疗效优于佐米曲普坦组(P<0.05)。结论 GBP能明显降低偏头痛患者CA出现率,对偏头痛患者中枢敏感化具有一定疗效。Objective： To investigate the effect of gabapentin on migrainal central sensitization. Methods： The patients were randomly divided into gabapentin group and Zolmitriptan control group,with 43 people in each group,and the course of treatment was 1 day. CA symptom checklist was used to measure the central sensitization before the treatment（ 2 hours after the attack of migraine） and after the treatment. Results： Two hours after the attack of migraine,CA emerged in 58 people,occurrence rate was 67. 4%,and the occurrence rate of slight CA degree was 24. 4%,moderate degree 19. 8%and severe degree 22. 8%. Compared with CA occurrence rates in the two groups before treatment,they decline significantly after treatment（ P〈 0. 05,P 0. 01）; The effect in gabapentin group was better than that in Zolmitriptan group（ P〈 0. 05）. Conclusion： Gabapentin can reduce significantly the CA occurrence rate of migraine,and it has certain central sensitization efficacy on the migrainal patients.

关 键 词：偏头痛 加巴喷丁 中枢敏感化 痛觉异常 

分 类 号：R747.2[医药卫生—神经病学与精神病学]