血清中IgE水平与胶质瘤发展关系的研究  

Study on Relationship between the Level of Serum IgE Related and Glioma Development

作　　者：陈南耀 蔡毅[2] 

机构地区：[1]海南省海口市第四人民医院神经内科,海口571100 [2]海南省农垦总局医院神经内科,海口570311

出　　处：《中国医药导刊》2014年第6期942-943,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:检测患者血清IgE浓度水平,探索其作为预测胶质瘤不同病理阶段的血清分子标志物的可行性。方法:收集胶质瘤患者110例,同时收集健康志愿者25名,非中枢神经系统肿瘤患者25例。在治疗前抽取4毫升静脉血,检测血清IgE的水平。结果:我们发现,肿瘤对照组的IgE水平和健康对照组没有显著性区别,但是胶质瘤组却显著低于健康对照组。此外,在胶质瘤组内,随着恶性程度升高,我们发现IgE水平出现了进一步的降低。结论:该研究表明,血清IgE水平可能随着胶质瘤程度增高而降低,提示着血清IgE水平可能能够作为血清标志物用于预测胶质瘤情况。Objective：To investigate the relations between serum IgE and the different stages of glioma,and try to figure out whether serum IgE could be considered as a biomarker to predict glioma’s development.Methods：110 cases of glioma patients were assigned to 3 groups based on the different glioma stages.25 cases of healthy volunteer and 25 non-CNS tumor patients were also included as control group.4ml of venous blood was collected,and serum IgE were detected.Results：The serum IgE level showed significant decrease in glioma patients compare with healthy group,and showed a further decrease with glioma stages increase.Conclusion：We found IgE would decrease with exacerbation of glioma situation,which suggested serum IgE may be considered as a potential biomarker for glioma.

关 键 词：胶质瘤 血清标记物 血清IgEa 

分 类 号：R739.4[医药卫生—肿瘤]