甘露聚糖肽序贯联合CapeOX化疗方案治疗Ⅳ期结肠癌的疗效观察  

Effects of Mannatide Sequential Therapy Combined with CapeOX Chemotherapy in the Treatment of StageⅣColon Cancer

作　　者：周冬兵 蒲敏 何林祥 

机构地区：[1]四川省南充市中心医院消化科,南充637000

出　　处：《中国医药导刊》2014年第6期1032-1033,1035,共3页Chinese Journal of Medicinal Guide

摘　　要：目的：探讨序贯甘露聚糖肽联合CapeOX化学治疗（化疗）方案治疗Ⅳ期结肠癌的临床疗效。方法：选择2005年2月~2011年10月期间笔者所在医院收治的Ⅳ期结肠癌患者120例,随机分为治疗组、对照组、安慰组,各40例,均施CapeOX化疗方案,同时治疗组住院期间应用甘露聚糖肽注射液,出院后口服甘露聚糖肽胶囊;对照组患者住院期间使用注射用胸腺肽,出院后口服胸腺肽肠溶胶囊,安慰组患者住院期间使用等体积的注射用生理盐水,出院后口服相同剂量淀粉安慰剂。结果：治疗组总有效为67.50%,均高于对照组和安慰组。Ⅲ~Ⅳ度毒副反应发生率为42.50%,与对照组、安慰组比较差异具有统计学意义（P〈0.01）。治疗组中位生存期为16.38个月,1年生存率为72.50%,与对照组、安慰组比较差异均具有统计学意义（P〈0.05）。结论：甘露聚糖肽序贯治疗晚期结肠癌能有效提高临床疗效,延长生存时间,且降低化疗毒副反应。Objective：To observe the efficacy of Mannatide sequential therapy combined with CapeOX chemotherapy in the treatment of stage Ⅳ colon cancer.Methods：120 patients with stage Ⅳ colon cancer in the hospital where the author stayed were selected from February 2005 to October 2011 and were randomly divided into treatment group and control group,each group had 40 cases respectively.Both groups were applied CapeOX chemotherapy,the treatment group were given Mannatide injection during hospitalization, oral administration of Mannatide capsules after discharge;the control group were given thymosin injection during hospitalization,oral administration of thymosin enteric-coated capsules after discharge,the placebo group were given an equal volume of saline injection during hospitalization,oral administration of the same dose starch placebo after discharge.Results：The total effective of treatment group was 67.50%,which was higher than that of the control and placebo group.The incidence of Ⅲ~Ⅳ degree of toxicity was 42.50%,with statistically significant difference from the control group and the placebo group（P〈0.01）.The median survival of treatment group was 16.38 months,1 year survival rate was 72.50%,with statistically significant differences from the control group and the placebo group（P〈0.05）.Conclusion：The treatment that Mannatide sequential therapy combined with CapeOX chemotherapy in the treatment of stage Ⅳcolon cancer can improve the clinical efficacy effectively,prolong survival time and reduce the side effects of chemotherapy.

关 键 词：甘露聚糖肽 序贯 结肠癌 化疗 CapeOX 

分 类 号：R735.35[医药卫生—肿瘤]