血清尿酸、胱抑素C与急性脑梗死的相关性研究  

Study on the relationship between Serum uric acid and Cys-C level in patients with acute cerebral infarction

作　　者：姚恩生[1] 唐燕[2] 王宏[1] 张云霞[1] 刘春红[1] 申婧[1] 

机构地区：[1]石河子大学医学院第一附属医院神经内科,新疆石河子832008 [2]石河子大学医学院第一附属医院老干科,新疆石河子832008

出　　处：《农垦医学》2014年第4期294-296,共3页Journal of Nongken Medicine

基　　金：石河子大学医学院第一附属医院基金项目(SS2008-072)

摘　　要：目的:探讨尿酸、胱抑素C(Cystatin C)与急性脑梗死的关系。方法:选取我院2012年1月-2013年12月收治的268例急性脑梗死患者为病例组,选取同期来我院体检的242名健康者为对照组,检验其血清中尿酸、胱抑素C、血脂等指标。结果:病例组患者的尿酸及Cystatin C水平明显高于对照组,差异有统计学意义(<0.05),Logistic回归分析显示尿酸(OR=0.538,=0.027)、胱抑素C(OR=17.671,=0.001),均是急性脑梗死的危险因素,经控制其他因素后,血清胱抑素C与急性脑梗死仍密切相关(OR=19.987,=0.001)。结论:血清尿酸及胱抑素C与急性脑梗死的发生密切相关,在急性脑梗死发生发展起到一定的作用,血清胱抑素C可能是急性脑梗死独立危险因素。Objective： To study of the relationship between Serum uric acid and Cys-C level in patients with acute cerebral infarction. Metheds：Selected from January 2012 to December 2013 treated 268 cases of acute cerebral infarction patients（case group）,and at the same time to the hospital physical examination of 242 healthy subjects（control group）,test the serum uric acid,Cystatin C（Cys-C）,blood lipids and other indicators. Results：The patient＇s level of uric acid and Cystatin C cases group was obviously higher than that of control group, the difference was statistically significant（P〈 0.05）,Logistic regression analysis showed that uric acid（OR=0.538, =0.538）in inhibition C（OR=17.671, =17.671）,is a risk factor for acute cerebral infarction, after controlling other factors,serum Cys C are closely associated with acute cerebral infarction is still（OR=19.987, =19.987）. Conclusion：Serum uric acid and Cys C is closely related to the occurrence of acute cerebral infarction, occurrence and development play a role in acute cerebral infarction,serum Cys C may be independent risk factors of acute cerebral infarction.

关 键 词：急性脑梗死 尿酸 胱抑素C 

分 类 号：R743.33[医药卫生—神经病学与精神病学]