不同剂量阿托伐他汀降脂对急性缺血性卒中患者颅内血管微栓子的影响  

Effect of Different Doses of Lipid Lowering with Atorvastatin on Intracranial Vascular Microemboli in Patients with Acute Ischemic Stroke

作　　者：何晋涛[1] 李尧[1] 唐华[1] 白维[1] 刘阳[1] 张娟[1] 

机构地区：[1]北京市第六医院神经内科,北京100007

出　　处：《中国医药导刊》2014年第9期1217-1218,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:了解不同剂量阿托伐他汀降脂对急性缺血性卒中患者颅内血管微栓子的影响。方法:将入组的100例患者随机分为2组研究,每组各50例。分别使用阿托伐他汀20mg及10mg剂量降脂治疗。同时在患者入院的第1天及第7天再行微栓子监测,观察栓子数目变化。并观察入院第2天及1周后LDL-C变化情况,及不良反应情况。结果:本研究发现10mg,20mg不同剂量阿托伐他汀降脂幅度分别45.24%﹑50.87%,阿托伐他汀在短期内均能使LDL平均降幅在40%以上;不同剂量他汀组微栓子数量减少上无明显差异。结论:不同剂量阿托伐他汀在卒中早期均能达到强化降脂作用,并减少微栓子数量,但大剂量阿托伐他汀降脂幅度更大,建议在卒中早期使用较大剂量阿托伐他汀进行降脂治疗,然后根据个体变化进行剂量调整,以达到更好的降脂标准,使患者获得更好的治疗。Objective：To investigate the effects of different doses of atorvastatin on patients with acute ischemic stroke and intracranial vascular microemboli.Methods：100 patients were divided randomly into group into 2 groups, 50 patients in each group.Using atorvastatin 20mg and 10mg dose lipid-lowering therapy.At the same time,ifrst days and 7 days in patients admitted to microemboli monitoring,to observe the changes in the number of embolus.And to observe the changes of LDL-C second days after admission and 1 weeks later, and adverse reaction.Results：The study found that 10mg,20mg of different doses of atorvastatin amplitude were 45.24%, 50.87%,atorvastatin in the short term can make the LDL average decline in more than 40%;the number of different doses of simvastatin group had no signiifcant difference on the reduction of microemboli. Conclusion：The effects of different doses of atorvastatin in early stroke can achieve intensive lipid-lowering effect,and reduce the number of microemboli, but high dose atorvastatin bigger,in stroke with higher dosage of atorvastatin early atorvastatin of lipid-lowering treatment, then according to the individual change of dose adjustment,in order to achieve lipid lowering standards better, treatment of the patients get better.

关 键 词：阿托伐他汀 降脂 经颅多普勒超声 微栓子监测 

分 类 号：R743.3[医药卫生—神经病学与精神病学]