人尿激肽原酶对缺血区脑灌注的影响和机制研究  

Influence and Mechanism of Human Urine Activated Peptides Enzyme to Ischemic Cerebral Perfusion

作　　者：张雪玲[1] 李丹[1] 陈念东[1] 马芸[1] 庞伟[1] 林晓光[1] 

机构地区：[1]南京鼓楼医院集团宿迁市人民医院神经内科,南京223800

出　　处：《中国医药导刊》2014年第12期1473-1474,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:研究分析人尿激肽原酶对缺血区脑灌注的影响和机制。方法:选取在我院采用缺血区脑灌注进行治疗的120例脑梗死患者,将患者随机分成实验组和对照组,平均每组60例患者,对照组的患者采用静滴丹参川芎嗪和奥扎格雷钠治疗,实验组的患者采用静滴丹参川芎嗪和人尿激肽原酶(尤瑞克林)治疗。观察两组患者在治疗前后的神经细胞功能的情况及治疗后的临床疗效。结果:治疗后,实验组患者的NIHSS评分和m RS指数均明显低于对照组的患者,在统计学上有意义(P<0.05);实验组患者的总有效率(91.67%)明显高于对照组患者的总有效率(66.67%),在统计学上有意义(P<0.05)。结论:对于采用缺血区脑灌注的患者同时给予人尿激肽原酶治疗,可以使患者的脑缺血再灌注损伤得到保护,使神经细胞凋亡减轻,可以有效的使缺血脑组织能量和供氧效果得到改善,使脑缺血后的血管再生效果得到促进,对脑梗死患者的治疗有显著的临床疗效。Objective： To observe and analyze the influence and mechanism research of human urine activated peptides enzyme to ischemic cerebral perfusion. Methods： Divide 120 cerebral infarction patients who were treated by ischemic cerebral perfusion in our hospital into experimental group and control group equally. Patients in the control group using intravenous drip of Danshen Ligustrazine and sodium ozagrel treatment, experimental group were treated with intravenous drip of Salvia miltiorrhiza Ligustrazine and human urinary kallikrein（Yurek Lin） treatment. Observe the nerve cell function before and after treatment and the clinical efficacy after treatment. Results： The NIHSS score and m RS index of experimental group patients were significantly lower than the control group, statistically significant（P〈0.05）; The total effective rate of experimental group（91.67%） is significantly higher than the control group total effective rate（66.67%）, statistically significant（P〈0.05）. Conclusion： For patients with ischemic cerebral perfusion, if giving them human urine excitation peptide enzyme treatment at the same time, their cerebral ischemia re-perfusion injury can be protected, relieve nerve cell apoptosis, improve the energy and oxygen supply effectively and promote the speed of angiogenesis after ischemia, It has significant curative effect to cerebral infraction patients.

关 键 词：人尿激肽原酶 缺血区脑灌注 影响 机制 

分 类 号：R743.32[医药卫生—神经病学与精神病学]