舒芬太尼自控静脉镇痛对肺癌术后血流动力学及免疫功能的影响  

Influence of sufentanil patient-controlled intravenous analgesia on postoperative blood dynamics and immune function in patients with lung cancer surgery

作　　者：吕德荣 张景晖 王龙鳞 

机构地区：[1]甘肃省武威市人民医院麻醉科,甘肃武威733000

出　　处：《实用临床医药杂志》2015年第7期94-96,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨舒芬太尼自控静脉镇痛对肺癌术后血流动力学及免疫功能的影响。方法 130例接受肺癌切除术的患者根据术后自控镇痛方案分为2组。观察组患者接受舒芬太尼自控镇痛,对照组患者接受芬太尼自控镇痛。比较2组患者的血流动力学指标、体液免疫功能及细胞免疫功能。结果观察组红细胞聚集指数、毛细血管血浆黏度、全血黏度、全血还原黏度均显著低于对照组(P<0.05);观察组患者的Ig G、Ig A、Ig M含量及CD4+T细胞含量显著高于对照组,CD8+T细胞含量显著低于对照组(P<0.05)。结论舒芬太尼自控静脉镇痛能改善血流动力学指标,增强细胞免疫和体液免疫功能。Objective To explore the influence of sufentanil patient-controlled intravenous analgesia on postoperative blood dynamics and immune function in patients with lung cancer surgery.Methods A total of 130 patients with lung cancer resection were divided into two groups according to different patient-controlled intravenous analgesia scheme. Observation group was treated with sufentanil patient-controlled intravenous analgesia,and control group was treated with fentanyl patient-controlled intravenous analgesia. Hemodynamic indexes,humoral immunity and cell immune function were compared between two groups. Results In the observation group,red cell aggregation index,blood plasma viscosity,whole blood viscosity,whole blood reduction viscosity were significantly lower than those in the control group（ P〈0. 05）. Contents of Ig G,Ig A and Ig M and CD4＋T cells level in the observation group were significantly higher than those in the control group,CD8＋T cells level was significantly lower than the control group（ P〈0. 05）. Conclusion Sufentanil patient-controlled intravenous analgesia can improve hemodynamic indexes and enhance cellular immunity and humoral immunity.

关 键 词：肺癌 静脉自控镇痛 舒芬太尼 血流动力学 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]