一种高灵敏度检测4-甲基咪唑的电化学阻抗传感器  

A Electrochemical Impedance Sensor for Highly Sensitive Detection of 4-Methylimidazole

作　　者：李伟[1] 赵常志[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《青岛科技大学学报（自然科学版）》2015年第2期136-140,共5页Journal of Qingdao University of Science and Technology:Natural Science Edition

摘　　要：以2,5-二巯基-1,3,4-噻二唑、乙酰丙酮和MnCl2为原料,采用简单的水溶液反应合成了水溶性化合物Mn（HL）2（H2O）2（HL=2-巯基-5-（乙酰丙酮-硫-噻二唑））,并将其自组装在金电极表面上,制备了一种新型的电化学阻抗传感器。利用该传感器对咪唑类化合物的选择性响应,实现了对可口可乐、百事可乐中的致癌物4-甲基咪唑的高灵敏度测定。在优化的实验条件下,传感器的电荷转移电阻与5.00×10-5~2.00×10-3μg·L-1范围内的4-甲基咪唑质量浓度呈线性关系,线性相关系数为0.999 2,检出限为8.00×10-6μg·L-1,对实际样品测定的相对标准偏差（RSD）小于1.98（n=5）,加标回收率为93.2%~95.2%。A water-soluble complex Mn（HL）2（H2O）2（HL=2-thiol-5-（acetylacetone）-sulfur-thiadiazole）was prepared based on simple reaction in aqueous solution by using2,5-dimercapto-1,3,4-thiadiazole,acetyl acetone and MnCl2 as raw material.And Mn-（HL）2（H2O）2was self-assembled on the gold electrode surface to prepare a novel electrochemical impedance sensor.As basis of the selective response of the sensor to imidazole compounds,the carcinogenic 4-methylimidazole was determined in Coca-Cola and Pepsi-Cola.Under the optimum conditions,the charge transfer resistances of the sensor were proportional to concentration of 4-methylimidazole in 5.00×10-5—2.00×10-3μg·L-1 range with a linear correlation coefficient of 0.999 2,and the detection limit for 4-methylimidazole was estimated to 8.00×10-6μg·L-1.The relative standard deviation was less than 1.98（n =5）and the recovery was in the range of 93.2%—95.2%for the determination of actual samples.

关 键 词：电化学阻抗传感器 2 5-二巯基-1 3 4-噻二唑 4-甲基咪唑 可口可乐 百事可乐 

分 类 号：O657.1[理学—分析化学]