TIP30和 VEGF －C 在小细胞肺癌中的表达及临床意义  

The clinic significance of TIP30 and VEGF-C protein expressions in small cell lung cancer

作　　者：李晓莉[1] 高伊娜[1] 李建慧 王艳颖[3] 马玉彦[4] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院呼吸内科,哈尔滨150081 [2]哈尔滨市胸科医院肿瘤内科 [3]哈尔滨医科大学附属肿瘤医院病理科 [4]哈尔滨医科大学肿瘤防治研究所

出　　处：《实用肿瘤学杂志》2015年第2期116-121,共6页Practical Oncology Journal

基　　金：黑龙江省教育厅面上项目资助（12521279）

摘　　要：目的：分析TIP30和血管内皮生长因子－C（ VEGF－C）在局限期小细胞肺癌（ SCLC）中的表达和临床意义。方法免疫组化法检测68例SCLC原发灶中TIP30和VEGF－C的表达。结果68例SCLC组织中TIP30和VEGF－C阳性表达率分别为51．5％（35／68）、54．4％（37／68）。 VEGF－C表达与淋巴结转移和肿瘤大小相关（P＜0．05），与患者的年龄、性别和吸烟之间差异无统计学意义（P＞0．05）。TIP30表达与患者的年龄、性别、吸烟、淋巴结转移和肿瘤大小之间的差异无统计学意义（ P＞0．05）。VEGF－C与TIP30表达呈负相关。 TIP30表达阳性SCLC患者的DFS和OS较长。相反，VEGF－C表达阳性SCLC患者的DFS和OS较短。 Cox多因素分析提示TIP30和VEGF－C表达是SCLC独立不良预后因素（P＜0．01）。结论 VEGF－C表达与淋巴结转移相关，TIP30阴性和VEGF－C阳性表达的SCLC患者预后差。Objective To investigate the correlation between TIP 30 and VEGF-C expression and clini-cophathological characteristics in resected small cell lung cancer （ SCLC） patients and to identify patients with in-creased risk of cancer recurrence and to provide a theoretical basis for the further clinical prevention of SCLC . Methods Sixty eight resected SCLC patients were included in this study .Paraffin-embedded specimens of pa-tients were used for the evaluation of TIP 30 and VEGF-C expression by immunohistochemistry .Results The expression of VEGF-C had positive correlation with lymph node metastasis .TIP30 expression was positively cor-related with VEGF-C expression.Patients with low TIP30 expression had shorter Overall survival （OS）and Dis-ease-Free survival（DFS）than those with high TIP30 expression.OS and DFS of the patients with VEGF -C-positive tumors were significantly lower than that of the patients with VEGF -C negative tumors .The multivariate Cox regression analysis showed that low TIP 30 and high VEGF-C expression were independent markers of poor OS（P〈0.01）in operable SCLC patients.Conclusion The expression of VEGF -C shows positive correlation with lymph node metastasis .Low TIP30 and high VEGF -C expression are independent prognostic markers of poor overall survival in resected SCLC patients .

关 键 词：TIP30 血管内皮生长因子-C 小细胞肺癌 淋巴转移 

分 类 号：R734.2[医药卫生—肿瘤]