TAP 检测在消化道肿瘤诊断和预后判断中的意义  

The si gnificances tumor abnormal p rotein detection for diagnosis and prediction of prognosis in gastroin-tetsinal tumors

作　　者：姚淞元[1] 吴永梅[1] 

机构地区：[1]新疆医科大学第五附属医院体检中心,乌鲁木齐830011

出　　处：《实用肿瘤学杂志》2015年第2期122-126,共5页Practical Oncology Journal

基　　金：2014年新疆维吾尔自治区科技支疆项目（201491180）

摘　　要：目的：探讨异常糖链糖蛋白（TAP）作为消化道肿瘤（GITs）诊断、预后判断指标的可能性。方法选取新疆医科大学第五附属医院门诊或住院的病例、健康体检者为研究对象，将其分为GITs患者组120例、GITs高危人群组123例和正常人群组117例；检测3组研究对象TAP的表达，并随访1年半，分析TAP表达与肿瘤发生或复发的关系。结果三组间TAP阳性＋临界表达率存在统计学差异（ P＜0．001）；TAP诊断GITs的灵敏度、特异度、阳性预测值、阴性预测值和约登指数分别为88．33％、85．83％、75．71％、93．64％和0．74；非 GITs 人群 TAP 阳性者肿瘤发生比例（23．53％）显著高于 TAP 阴性者（0．49％）（P＜0．001）；GITs患者TAP阳性者复发率（33．33％）显著高于阴性者（6．90％）（P＜0．001）。结论 TAP可以作为消化道肿瘤诊断、早期预防、疗效监测以及预后判断的指标。Objective To investigate the possibility of tumor abnormal protein （ TAP） ,as index of diag-nosis and prediction of prognosis in gastrointestinal tumors （GITs）.Methods The outpatients and inpatients as well as healthy physical examinees in our hospital were chosen as objects in the present study .The patients were divided into GIT group（120 cases）,high-risk GIT group（123 cases）and normal group（117 cases）.TAP ex-pression was detected in three groups.These study objects were followed up for one and a half years .Then the re-lationship between TAP expression and the occurrence or recurrence of tumors was analyzed .Rseults There were significant differences（P〈0.001）among the three groups on the positive TAP with critical expression rate .TAP detections to GITs diagnosis sensitivity ,specificity ,positive predictive value ,negative predictive value and Youden index were 88.33%,85.83%,75.71%,93.64% and 0.74 respectively.TAP positive non GITs crowd tumori-genesis proportion （23.53%）was significantly higher than that of TAP -negative（0.49%）（P〈0.001）.GITs TAP positive patients relapse rate（33.33%）was significantly higher than negative ones （6.90%）（P〈0.001）. Conlcusion TAP can be an index for diagnosis ,early prevention ,monitoring of treatment effect and prediction of prognosis of gastrointestinal tumor .

关 键 词：异常糖链糖蛋白 检测 消化道肿瘤 早期诊断 发生率 

分 类 号：R735[医药卫生—肿瘤]