基于关联规则和熵聚类的颜正华教授治疗心系病证用药规律研究  

Study on professor Yan Zhenghua's medication regularity in treating heart diseases based on association rules and entropy cluster

作　　者：吴嘉瑞[1] 郭位先[1] 张晓朦[1] 张冰[1] 张月[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中国中药杂志》2015年第8期1601-1604,共4页China Journal of Chinese Materia Medica

基　　金：国家科技支撑计划项目(2007BAI10B01);北京市中医药科技发展基金项目(JJ-2010-70);北京市与中央在京高校共建项目(BJGJ1420);北京中医药大学科研创新团队项目(2011-CXTD-14);北京中医药大学"重点学科"开放项目(2013-ZDXKKF-19)

摘　　要：收集了颜正华教授治疗心系病证的病案,采用关联规则apriori算法和复杂系统熵聚类等数据挖掘方法,确定处方中各种药物的使用频次及药物之间的关联规则等,分析颜正华教授治疗心系病证的用药经验。结果显示,高频次药物包括丹参、炒酸枣仁、首乌藤、牡蛎、茯苓等,高频次药物组合包括牡蛎-龙骨、首乌藤-炒酸枣仁、丹参-炒酸枣仁等,置信度为1的关联规则包括降香→丹参、薤白→丹参、龙骨→牡蛎、丹参,龙骨→牡蛎等,核心组合包括白菊花-天麻-白蒺藜、续断-桑寄生-牛膝、珍珠母-首乌藤-柏子仁-龙骨等。In this study, Professor Yan Zhenghua＇s recipes for treating heart diseases were collected to determine the frequency and association rules among drugs by such data mining methods as apriori algorithm and complex system entropy cluster and summarize Pro- fessor Yan Zhenghua＇s medication experience in treating heart diseases. The results indicated that frequently used drugs included Salvi- ae Miltiorrhizae Radix et Rhizoma, Parched Ziziphi Spinosae Semen, Polygoni Multiflori Caulis, Ostreae Concha, Poria; frequently used drug combinations included ＂Ostreae Concha, Draconis Os＂ , ＂ Polygoni Multiflori Caulis, Parched Ziziphi Spinosae Semen＂ , and ＂Salviae Miltiorrhizae Radix et Rhizoma, Parched Ziziphi Spinosae Semen＂. The drug combinations with the confidence of 1 included ＂Dalbergiae Odoriferae Lignum→Salviae Mihiorrhizae Radix et Rhizoma＂ , ＂ Allii Macrostemonis Bulbus→Parched Ziziphi Spinosae Semen＂ , ＂Draconis Os→Ostreae Concha＂, and ＂Salviae Miltiorrhizae Radix et Rhizoma, Draconis Os→Ostreae Concha＂. The core drug combinations included ＂Chrysanthemi Flos-Gastrodiae Rhizoma-Tribuli Fructus＂, ＂ Dipsaci Radix-Taxillus sutchuenensis- Achy- ranthis Bidentatae Radix＂ , and ＂Margaritifera Concha-Polygoni Multiflori Caulis-Platycladi Semen-Draconis Os＂.

关 键 词：颜正华 心系病证 关联规则 聚类算法 

分 类 号：R259[医药卫生—中西医结合] TP311.13[医药卫生—中医内科学]