改善记忆肽研究进展  

Research Progress of Memory Improving Peptides

作　　者：赵谋明[1,2] 赵甜甜[1,2] 苏国万[1,2] 

机构地区：[1]华南理工大学轻工与食品学院,广东广州510640 [2]广东省食品绿色加工与营养调控研发中心,广东广州511400

出　　处：《食品科学技术学报》2015年第2期1-6,共6页Journal of Food Science and Technology

基　　金：广东省战略性新兴产业核心技术攻关项目(2012A080800014;2012A020800002)

摘　　要：记忆力的下降甚至退化与人体健康状况、大脑生理老化、大脑创伤以及病理性变化等有着密切的关系。除此之外,经济社会飞速发展所带来的压力也会导致不同年龄阶层的人出现记忆紊乱,从而影响其正常生活。目前针对因生理性老化或疾病而导致记忆退化改善的理论研究已有许多,但缺乏可用于各年龄段人群并可日常食用的改善记忆药物或保健品的研究和开发。肽类物质,不仅对维持脑细胞的代谢,保持大脑的各种正常运动具有重要贡献,而且具有原料来源广泛,制备工艺简单,稳定性强等优点。介绍了与改善记忆力有关的肽类物质及其制备方法,并对记忆改善的靶点和功效评价手段进行了概述。已有研究表明,以蛋白为原料制备的改善记忆肽具有提高动物学习记忆能力,改善脑组织、神经细胞病理状态的功能。该方面研究可为改善记忆肽促进儿童智力的开发,延缓成年人记忆力的减退,以及为阿尔茨海默病(老年痴呆)患者研制临床营养保健食品提供理论基础。Memory decline and degeneration can be associated with human health conditions,brain physiological aging,brain trauma,and pathologic changes. Due to the pressure caused by skyrocketing economic burden on society,from teenagers to the elderly all live with memory disorders. Different therapeutic approaches are available to treat or improve memory impairment during physiological aging and diseases. However,there are a few researches on materials about memory improving on all ages as daily supplements. Peptides,not only could maintain the metabolism of brain cells and keep the brain movement normal as supplements directly,but also show the superiorities of wild raw material sources,simple preparation technology,and strong stability. Therefore,it attracts people＇s attention as daily supplements.The memory improving peptides,its preparation methods,the targets of memory alleviation and the effects evaluation methods were summarized in this paper. It provides theoretical basis for peptides which are going to promote teenagers＇ intelligence,improve memory loss for adults and be clinical nutrition for Alzheimer＇s patients.

关 键 词：改善记忆 肽 制备方法 记忆靶点 评价手段 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]