胰岛素抵抗对帕金森病患者认知功能障碍的影响  

Effects of insulin resistance on cognitive impairment in patients with Parkinson's Disease

作　　者：黄婷婷[1] 

机构地区：[1]广东省佛山市中医院脑病科,528000

出　　处：《白求恩医学杂志》2015年第2期129-130,共2页Journal of Bethune Medical Science

摘　　要：目的研究胰岛素抵抗对帕金森病患者认知功能的影响,为早期预防帕金森认知功能障碍提供依据。方法选取帕金森病患者121例,对所有纳入者进行空腹血糖(FPG)、空腹胰岛素(FINS)测定,并应用相关量表对帕金森患者运动及认知功能障碍程度进行评估,分析帕金森病痴呆患者的胰岛素抵抗情况。结果 FPG、FINS和胰岛素抵抗指数(HOMAIR),重度认知功能障碍患者均高于中度和轻度认知功能障碍者(P均<0.05);进行非条件Logistic回归分析提示,导致帕金森病患者认知功能障碍进展的危险因素包括FINS和HOMA-IR。结论帕金森病患者认知功能障碍与胰岛素抵抗有密切关系。在临床上结合胰岛素抵抗情况早期给予诊治,可有效预防认知功能障碍加重,对患者的预后有重要意义。Objective To study the effects on cognitive function of patients with Parkinson＇s Disease（ PD） and insulin resistance and to provide the basis for early prevention of cognitive impairment in PD. Methods One hundred and twenty-one patients with PD were selected and all the patients were tested for fasting blood glucose（ FPG）,fasting insulin（ FINS） measurement,and the related scale was used to evaluate the movement of patients with PD and the degree of cognitive impairment to analyze the insulin resistance of PD patients with dementia. Results FPG,FINS and HOMA-IR in patients with severe cognitive dysfunction were higher than those of moderate and mild cognitive impairment（ P〈0. 05）. Non conditional Logistic regression analysis showed that the influence of risk factors of progression of cognitive impairment in PD included FINS and HOMA-IR. Conclusion Clinically,early intervention based on situation of insulin resistance can effectively prevent progression of cognitive function impairment with significant value for prognosis.

关 键 词：胰岛素抵抗 帕金森病 认知功能 相关性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]