硫辛酸对腹膜透析患者氧化应激、炎症及营养状况的影响  

Effect of lipoic acid on oxidative stress,inflammation and nutritional status in peritoneal dialysis patients

作　　者：程勇军[1] 寿张飞[1] 王文龙[2] 郑敏巧[2] 王怡倩[2] 郝世军[2] 李云生[2] 

机构地区：[1]浙江大学附属第一医院肾脏病中心,杭州310006 [2]温岭市第一人民医院,温岭317500

出　　处：《中国免疫学杂志》2015年第4期541-544,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金资助项目(No.81170707)

摘　　要：目的:探讨硫辛酸对腹膜透析患者氧化应激、炎症及营养状况的影响。方法:以腹膜透析患者为研究对象,随机分成观察组47例和对照组47例,两组均给予相同的常规治疗,观察组予硫辛酸胶囊(一次0.2g,一日3次)口服,疗程为12周。检测超氧化物歧化酶(SOD)、丙二醛(MDA)、血清晚期蛋白氧化产物(AOPPs)反映氧化应激水平,检测超敏CRP、IL-6和TNF-α反映微炎症状态,使用改良定量主观整体评估(MQSGA)、中臂围、中臂肌围、肱三头肌皮褶厚度(TSF)、体重指数(BMI)和血白蛋白反映营养状况。比较两组治疗前和治疗后氧化应激、微炎症状态和营养状况的差别。结果:1观察组治疗后AOPPs和MDA均显著低于治疗前,SOD显著高于治疗前,差异均有统计学意义(P<0.05);治疗后,观察组AOPPs和MDA均显著低于对照组,SOD显著高于对照组,差异均有统计学意义(P<0.05);2观察组治疗后超敏CRP、IL-6和TNF-α均显著低于治疗前,差异均有统计学意义(P<0.05);治疗后,观察组超敏CRP、IL-6和TNF-α均显著低于对照组,差异均有统计学意义(P<0.05);3观察组治疗后TSF、中臂围、中臂肌围、BMI和白蛋白均较治疗前显著升高,MQSGA较治疗前显著下降,差异均有统计学意义(P<0.05);治疗后,观察组MQSGA显著低于对照组,白蛋白显著高于对照组,差异均有统计学意义(P<0.05)。结论:硫辛酸可改善腹膜透析患者的氧化应激,从而改善微炎症状态和营养状况。Objective：To explore the effect of lipoic acid on oxidative stress,inflammation and nutritional status in peritoneal dialysis patients. Methods： 94 peritoneal dialysis patients were randomly divided into the observe group（ n = 47） the control group（ n =47）. They all accepted the conventional treatment,but the patients in the observed group were given the treatment of lipoic acid capsules（0. 2 g tid） for 12 weeks. Superoxide dismutase（SOD）,malondialdehyde（MDA）,serum advanced oxidation protein products（AOPPs）were used to reflect the level of oxidative stress,high sensitive CRP,IL-6 and TNF-α were used to reflect the micro inflammatory state,modified quantitative subjective global assessment（ MQSGA）,mid-arm circumference,mid-arm muscle circumference,triceps skinfold thickness（ TSF）,body mass index（ BMI）,and serum albumin were used to reflect the nutritional status. The difference of oxidative stress,micro inflammatory state and nutritional status were compared between the two groups. Results： 1In the observation group,the concentrations of AOPPs and MDA after treatment were significantly lower than that before treatment,and the concentration of SOD after treatment was significantly higher than that before treatment（ P〈0. 05）;after treatment,the concentrations of AOPPs and MDA in the observe group were significantly lower than that in the control group（ P〈0. 05）,and the concentration of SOD in the observe group was significantly higher than that in the control group（ P〈0. 05）. 2In the observation group,the concentrations of high sensitive CRP,IL-6 and TNF-α after treatment were significantly lower than that before treatment（ P〈0. 05）;after treatment,the concentrations of high sensitive CRP,IL-6 and TNF-α in the observe group were significantly lower than that in the control group（ P〈0. 05）. 3In the observation group,the TSF,mid-arm circumference,mid-arm muscle circumference,BMI and albumin after treatment were significantly higher than that be

关 键 词：硫辛酸 腹膜透析 氧化应激 炎症 营养 

分 类 号：R453.9[医药卫生—治疗学]