细胞自噬与急性肝损伤  

Autophgy and acute liver injury

作　　者：黄道斌[1] 钟佳[2] 邹书兵[1] 

机构地区：[1]南昌大学第二附属医院普通外科,南昌330006 [2]南昌大学第二附属医院消化内科,南昌330006

出　　处：《生命的化学》2015年第2期219-224,共6页Chemistry of Life

基　　金：江西省卫生厅科技计划项目(20094005)

摘　　要：细胞自噬是一种关键性的溶酶体降解途径,它能通过降解细胞中的一些成分,如受损的细胞器和细胞中的长寿蛋白质而维持细胞的生理功能和细胞存活。研究证据表明,自噬水平的变化是大量肝脏疾病发生发展的潜在机制,自噬在不同原因诱导的急性肝损伤中所起的作用并不完全相同,自噬水平的调节或可成为肝脏疾病治疗的新方向。本文将对自噬与急性肝损伤中相关性及可能的发生机制做一综述。Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. As the research showed, con- siderable evidence has proved that alterations of autophagy are an underlying mechanism in the processing of liver disease. The role autophagy plays is not completely go all the way, promoting or inhibiting autophagy can be a new therapeutic target. This paper will focus on the role and possible mechanism autophagy played in acute liver injury.

关 键 词：细胞自噬 线粒体自噬 急性肝损伤 

分 类 号：R575[医药卫生—消化系统]