射频消融联合肝动脉栓塞化疗治疗无法切除的结直肠癌肝转移瘤的疗效  

Effect iveness of radiofrequency ablation combined with transcatheter artery chemoembolization for unresectable colorectal liver metastases

作　　者：张世杰[1] 石明[2] 方万强[1] 付春利[1] 邓国敏[1] 

机构地区：[1]开平市中心医院外一科,江门529300 [2]中山大学肿瘤防治中心肝胆科

出　　处：《山西医科大学学报》2015年第4期356-359,共4页Journal of Shanxi Medical University

摘　　要：目的探讨经皮射频消融（RFA）联合肝动脉栓塞化疗（TACE）序贯性治疗结直肠癌肝转移瘤的疗效。方法分析2006-06～2010-06开平市中心医院62例无法手术切除的结直肠癌肝转移瘤患者,按治疗方法分为2组：联合组（RFA联合TACE）34例,TACE组28例。观察治疗后第1周肝功能变化;治疗后4周增强CT/MRI检查肿瘤坏死率的情况;治疗后的生存率。结果 TACE组和联合组比较：1周后肝功能变化,差异无统计学意义（P〉0.05）;治疗后肿瘤坏死率分别为60.7%（17/28）和90.41%（32/34）,差异有统计学意义（P〈0.05）;半年生存率分别为92.9%和97.1%,1,2,3年生存率联合组明显优于TACE组（P〈0.05）。结论对于无法手术切除的结直肠癌肝转移瘤,射频消融联合肝动脉栓塞化疗的治疗效果明显优于肝动脉栓塞化疗,且安全可靠,易于操作。Objectlve To access the effect of sequentlal percutaneous radlofrequency ablatlon（ RFA） comblned wlth transcateter artery chemoembollzatlon（ TACE） for colorectal llver metastases.Methods From June 2006 to June 2010,62 patlents wlth unresectable colorectal llver metastases were admltted ln Kalplng Center Hospltal,and then dlvlded lnto two groups：comblnatlon group（ RFA ＋ TACE,n = 34） and TACE group（ n = 28）.After treatment,llver functlon at 1 week after treatment,tumor necrosls rate by enhanced CT /MRl at 4 week after treatment,and the overall survlval rates were recorded.Results There was no slgnlflcant dlfference ln llver functlon at 1 week after treatment between these two groups（ P〉 0.05）.The tumor necrosls rate ln comblnatlon group was hlgher than that ln TACE group at 4 weeks after treatment（ 90.4% vs 60.7%,P〈 0.05）.The 1-,2-,3-year overall survlval rates ln comblnatlon group were hlgher than ln TACE group（ P〈0.05）.Concluslon RFA comblned wlth TACE ls safe and effectlve for unresectable colorectal llver metastases.

关 键 词：射频消融 肝动脉栓塞化疗 结直肠癌肝转移 生存率 

分 类 号：R735.37[医药卫生—肿瘤]