普拉洛芬滴眼液治疗干眼症效果分析  

Effectiveness of Pranoprofen Eye Drops in Treatment of Dry Eye Syndromes

作　　者：王莉[1] 王安之[1] 

机构地区：[1]安康市中心医院眼科,陕西安康725000

出　　处：《解放军医药杂志》2015年第4期67-71,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨普拉洛芬滴眼液对干眼症治疗的效果。方法选取2011年2月—2013年12月收治确诊为干眼症的患者80例,随机分为观察组、对照组,每组40例。对照组患者给予人工泪液治疗,观察组给予普拉洛芬滴眼液,治疗第1、2、3、4周,观察患者症状及检查结果变化。结果两组治疗3、4周后与治疗前比较,Schirmer I试验结果、泪液破裂时间显著延长(P<0.05),荧光染色实验评分、问卷调查分数显著降低(P<0.05)。治疗2、3、4周观察组泪膜破裂时间显著长于对照组,荧光素染色实验评分与干眼症状问卷结果均显著低于对照组(P<0.05)。治疗第4周,观察组总有效率显著高于对照组(P<0.05)。结论普拉洛芬在干眼症治疗中,较人工泪液疗效显著。Objective To investigate the effectiveness of Pranoprofen Eye Drops in treatment of patients with dry eye syndromes. Methods A total of 80 patients with dry eye syndromes admitted during February 2011 and December2013 were randomly divided into observation group（ n = 40） and control group（ n = 40）. The control group was treated with artificial tears,while the observation group was treated with Pranoprofen Eye Drops. The symptoms and changes of examination results of patients were observed during the 1^st,2^nd,3^rd and 4^th week of treatment. Results During the 3^rd and 4^th week of treatment,Schirmer I test results were significantly lengthened and tears ruptured times were significantly prolonged compared with those before treatment（ P〈0. 05）,and the scores of fluorescence staining test and questionnaire were significantly lower than those before treatment in the two groups（ P〈0. 05）. During the 2nd,3rdand 4thweek of treatment in observation group,breakup time of tear film was significantly longer,while the scores of fluorescence staining test and questionnaire were significantly lower than those the control group（ P〈0. 05）. After 4 weeks of treatment,the total effective rate of observation group was significantly higher than that of control group（ P〈0. 05）. Conclusion The Pranoprofen Eye Drops in treatment of dry eye syndromes may achieve better effect than that by artificial tears therapy.

关 键 词：普拉洛芬 干眼综合征 治疗结果 

分 类 号：R777.34[医药卫生—眼科]